Email：[email protected]
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Education
2009-2012??????????? Ph.D, the First Affiliated Hospital, Sun Yat-sen University, China.
2005-2008??????????? M.D Medical College of Nantong University, Jiangsu, China.
1991-1995??????????? Secondary Medical School, ?Laiyang Secondary Medical School, Shandong, China.
Employment history
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2017.07- present the Seventh Affiliated Hospital, Sun Yat-sen University, China
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2017.01- present Vice director, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology
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2016.03-2018.03 AO fellow, AO Research Institute, Davos, 7270 Switzerland
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2016.1-2017.06????? Associate professor, Spine Surgery Department/Orthopedic Research Institute, the First Affiliated Hospital, Sun Yat-sen University, China
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2012.11-2015.12?? Post-doctor, Medical School of Shenzhen University and Sun Yat-sen University
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2013.01-2014.12?? director of R & D, Guangzhou Yijie Medicine Technology Co., Ltd
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2012.6-2012.10??????? Research & Teaching Assistant, Spine Surgery Department/Orthopedic Research Institute, the First Affiliated Hospital, Sun Yat-sen University, China
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2008.01-2009.08 Attending Surgeon, Longkou traditional hospital, Shandong, China
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2005-2008??????? Research & Teaching Assistant, Medical College of Nantong University, China
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1995-2005??????? Surgeon,? Xiadingjia Hospital, Longkou, Shandong, China.
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Approved Research Projects(partly)
PI = Principal Investigator, CA = Co-Applicant, PR = Peer Reviewed
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Active memberships in scientific societies
Member of SICOT Committee.
Committee member of Orthopaedic Research Branch of Chinese Medical Society.
Prizes, awards, fellowships
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2014 |
COA Orthopaedics Research Awards 3rd Class |
List of Publications: Peer-reviewed articles
Total number of published articles: 70+; Total number of published first and corresponding author articles: 51
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1.? ? Zhou, Zhiyu#，Jiang, Bo，Zhou, Zhiyang,，Pan, Ximin,，Sun, Haixing,，Huang, Baoding,，Liang, Tangzhao,，Ringgaard, Steffen,，Zou, Xuenong*,，Intervertebral Disk Degeneration: T1 rho MR Imaging of Human and Animal Models，Radiology,，2013.8.01,，268（2）：492~500
2.? ? Zhang, P.#, X. Liu#, P. Guo#, X. Li, Z. He, Z. Li, M. J. Stoddart, S. Grad, W. Tian, D. Chen*, X. Zou*, Z. Zhou* and S. Liu (2021). "Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration." Bioactive Materials 6(10): 3097-3108. DOI:10.1016/j.bioactmat.2021.02.024.?
3.? ? Peng Guo#, Xizhe Liux#, Penghui Zhang#, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqiang Zhou, Xuenong Zou, Danny Channy, Wei Tian, Dafu Chen*, Manman Gao*, Zhiyu Zhou*, Shaoyu Liu A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration. Bioact Mater. 2021 Aug 11;9:281-298.?
4.? ? Ma J, Guo W, Gao M, Huang B, Qi Q, Ling Z, Chen Y, Hu H, Zhou H, Yu F, Chen K, Richards G, Lin J, Zhou Z*, Xiao D*, Zou X*. Biomimetic matrix fabricated by LMP-1 gene-transduced MC3T3-E1 cells for bone regeneration. Biofabrication. 2017 Nov 14;9(4):045010. doi: 10.1088/1758-5090/aa8dd1
5.? ? Zhou, Zhiyu, Wentao Wang, Jianmin Wang, Hongshui Wang, Yi Xia, Wei Zhang, Yuxiao Lai et al. "Function-oriented design: A novel strategy for advanced biomedical materials." Journal of Materials Science & Technology 145 (2023): 197-209.?
6.? ? Ma, Junxuan#，Zhou, Zhiyu#,，Gao, Manman,，Yu, Binsheng，Xiao, Deming*,，Zou, Xuenong*,，B¨1nger, Cody*，Biosynthesis of Bioadaptive Materials: A Review on Developing Materials Available for Tissue Adaptation,，Journal of Materials Science & Technology,，Volume 32, Issue 9, September 2016, Pages 810-814?
7.? ? Chen, Shaoming#，Gao, Manman#,，Zhou, Zhiyu#,，Liang, Jiabi，Gong, Ming,，Dai, Xuejun,，Liang, Tangzhao，Ye, Jiacheng,，Wu, Gang,，Zou, Lijin，wang yingjun，Zou Xuenong*,，Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia,，Journal of Materials Science & Technology(1005-0302)，2016.08.03,，32（9）：978~985?
8.? ? Zhou ZhiYu,，Zou LiJin，Li HaiSheng,，Bunger Cody,，Zou XueNong(*)，An overview on bone protein extract as the new generation of demineralized bone matrix,，Science China Life Sciences,，2012.12.01，55（12）：1045~1056?
9.? ? Li, Baoliang, Xu Chen, Hongkun Chen, Fu Zhang, Jianfeng Li, Zhengya Zhu, Tao Tang et al. "A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration." Biomolecules and Biomedicine 25, no. 3 (2025): 708-719.
10.? Wang, Fuan, Hongkun Chen, Zhongyuan He, Jianfeng Li, Zhengya Zhu, Tao Tang, Junhong Li et al. "Cellular response to short-time mechanical stimuli: mediating Ca 2+ influx via PIEZO1." European Cells and Materials 48 (2024): 1-16.
11.? Zhou, Jiaxiang, Jianmin Wang, Jianfeng Li, Zhengya Zhu, Zhongyuan He, Junhong Li, Tao Tang et al. "Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc." JOR spine 7, no. 1 (2024): e1314.
12.? ?Li, Junhong, Jianfeng Li, Chengkai Lin, Jiaxiang Zhou, Jianmin Wang, Fuan Wang, Haizhen Li, and Zhiyu Zhou. "Genetically proxied PCSK9 inhibition is associated with reduced psoriatic arthritis risk." Inflammation Research 73, no. 3 (2024): 475-484.
13.? ?Chen, Dafu, Jiaxiang Zhou, Chengkai Lin, Junhong Li, Zhengya Zhu, Xuezhi Rao, Jianmin Wang et al. "A causal examination of the correlation between hormonal and reproductive factors and low back pain." Frontiers in Endocrinology 15 (2024): 1326761.
14.? ?He, Zhongyuan, Tao Tang, Zhengya Zhu, Fuan Wang, Jianfeng Li, Fu Zhang, Nguyen Tran Canh Tung, Shaoyu Liu, Xizhe Liu, and Zhiyu Zhou. "Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes." JOR spine 7, no. 3 (2024): e1350.
15.? Li, Jianfeng, Junhong Li, Xianlong Li, Wei Wang, Yi Ding, Jiaxiang Zhou, Wentao Wang et al. "Identification of coagulation diagnostic biomarkers related to the severity of spinal cord injury." International Immunopharmacology 137 (2024): 112505.
16.? He, Zhongyuan, Zhengya Zhu, Tao Tang, Fuan Wang, Peng Guo, Jianfeng Li, Nguyen Tran Canh Tung et al. "Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging." Journal of Bone and Mineral Metabolism (2024): 1-18.
17.? Zhu, Z., T. Tang, Z. He, F. Wang, H. Chen, G. Chen, J. Zhou et al. "Uniaxial cyclic stretch enhances osteogenic differentiation of OPLL-derived primary cells via YAP-Wnt/β-catenin axis." Eur. Cell Mater 45 (2023): 31-45.
18.? Zhu Y, Lu Y, Zhou C, Tong G, Gao M, Zhan Y, Wang Y, Liang R, Li Y, Gao T, Wang L, Zhang M, Cheng J, Gong J, Wang J, Zhang W, Qi J, Cui M, Zhu L, Xiao F, Zhu L, Xu Y, Zheng Z, Zhou Z, Cheng Z, Hong P. Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines. Med (N Y). 2022 Jun 8:S2666-6340(22)00219-7. doi: 10.1016/j.medj.2022.05.003. Epub ahead of print. PMID: 35679856; PMCID: PMC9181311.
19.? Bao-Liang Li, Xizhe Liu, Manman Gao, Fu Zhang, Xu Chen, Zhongyuan He, Jianmin Wang, Wei Tian, Dafu Chen*, Zhiyu Zhou*, Shaoyu Liu Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Oxid Med Cell Longev . 2021 Aug 31;2021:5608133. doi: 10.1155/2021/5608133. eCollection
20.? Zhu Z, He Z, Tang T, Wang F, Chen H, Li B, Chen G, Wang J, Tian W, Chen D, Wu X, Liu X, Zhou Z, Liu S. Integrative Bioinformatics Analysis Revealed Mitochondrial Dysfunction-Related Genes Underlying Intervertebral Disc Degeneration. Oxid Med Cell Longev. 2022 Oct 11;2022:1372483. doi: 10.1155/2022/1372483. PMID: 36267810; PMCID: PMC9578809.?
21.? Chen X#, Chen H#, Li BL, Xiao Z, Zhou Y, Tian W, Chen D, Liu X*, Zhou Z*, Liu S. Dynamic elastic modulus assessment of the early degeneration model of an intervertebral disc in cynomolgus monkeys with one strike loading. Comput Methods Programs Biomed. 2022 Jun 30;224:106982. doi: 10.1016/j.cmpb.2022.106982. Epub ahead of print. PMID: 35797747.?
22.? Gao M, Liu X, Guo P, Wang J, Li J, Wang W, Stoddart MJ, Grad S, Li Z, Wu H, Li B, He Z, Zhou G, Liu S, Zhu W*, Chen D*, Zou X*, Zhou Z*. Deciphering postnatal limb development at single-cell resolution. iScience. 2022 Dec 13;26(1):105808. doi: 10.1016/j.isci.2022.105808. PMID: 36619982; PMCID: PMC9813795.?
23.? Zhang F*, Wang S*, Gao M, Li B, He Z, Tang T, Zhu Z, Liu S#, Zhou Z#. Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation. Front Bioeng Biotechnol. 2022 Dec 16;10:1057429. doi: 10.3389/fbioe.2022.1057429. PMID: 36588938; PMCID: PMC9800418.?
24.? Zhang F, Wang S, Gao M, Li B, He Z, Tang T, Zhu Z, Liu S, Zhou Z. Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation. Front Bioeng Biotechnol. 2022 Dec 16;10:1057429. doi: 10.3389/fbioe.2022.1057429. PMID: 36588938; PMCID: PMC9800418.
25.? He Z, Zhu Z, Tang T, Guo P, Gao M, Li B, Nguyen TCT, Chen H, Liu X, Zhou Z, Liu S. Characterization of ligamentum flavum hypertrophy based on m6A RNA methylation modification and the immune microenvironment. Am J Transl Res. 2022 Dec 15;14(12):8800-8827. PMID: 36628248; PMCID: PMC9827295.
26.? Zhiyu Zhou, Shangbin Cui, Jie Du, R. Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li. One Strike Loading Organ Culture Model to Investigate the Post-traumatic Disc Degenerative Condition. J Orthop Translat. 2020 Oct 20;26:141-150. doi: 10.1016/j.jot.2020.08.003. eCollection 2021 Jan.?
27.? Zhiyu Zhou , Stephan Zeiter , Tanja Schmid , Daisuke Sakai , James C. Iatridis , Guangqian Zhou , R. Geoff Richards, Mauro Alini , Sibylle Grad , and Zhen Li Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration ?Cartilage 2020 https://doi.org/10.1177/1947603518764263
28.? Wen L, Gao M, He Z, Guo P, Liu Z, Zhang P, Zhang F, Chen D, Zhou G, Zhou Z. Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis. Biochem Biophys Res Commun. 2021 Sep 17;570:199-205. doi: 10.1016/j.bbrc.2021.07.044. Epub 2021 Jul 20. PMID: 34298323..?
29.? Tang, Tao, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu#, Zhiyu Zhou#, Shaoyu Liu. "DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling." JOR Spine (2023): e1247.?
30.? Wang J, Zhu P, Pan X, Yang J, Wang S, Wang W, Li B, Zhu Z, Tang T, Chen D, Gao M, Zhou Z. Correlation between motor behavior and age-related intervertebral disc degeneration in cynomolgus monkeys. JOR Spine. 2022 Jan 1;5(1):e1183. doi: 10.1002/jsp2.1183. PMID: 35386757; PMCID: PMC8966873.?
31.? F. Zhang#, S. Wang#, B. Li, W. Tian, Z. Zhou*, S. Liu*, Intradiscal injection for the management of low back pain, JOR SPINE 2021 n/a(n/a) e1186.?
32.? S. Cui, Z. Zhou#, X. Chen, F. Wei, R.G. Richards, M. Alini, S. Grad, Z. Li, Transcriptional profiling of intervertebral disc in a post-traumatic early degeneration organ culture model, JOR SPINE 2021 Apr 8;4(3):e1146. doi: 10.1002/jsp2.1146. eCollection 2021 Sep.?
33.? Zhengya Zhu, Tao Tang, Zhongyuan He, Fuan Wang, Hongkun Chen,，Guoliang Chen , Jiaxiang Zhou, Shengkai Liu, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu#, Zhiyu Zhou#, Shaoyu Liu ?Uniaxial Cyclic Stretch Enhances Osteogenic Differentiation of OPLL Derived Primary Cells via YAP-Wnt/β-catenin Axis eCM 2023 2023 Feb 7;45:31-45. doi: 10.22203/eCM.v045a03.
34.? He Z, Zhu Z, Tang T, Guo P, Gao M, Li B, Nguyen TCT, Chen H, Liu X#, Zhou Z#, Liu S. Characterization of ligamentum flavum hypertrophy based on m6A RNA methylation modification and the immune microenvironment. Am J Transl Res. 2022 Dec 15;14(12):8800-8827. PMID: 36628248; PMCID: PMC9827295.
35.? Li J, Wu H, Liu X, Guo P, He Z, Wen L, Tian W, Chen D, Gao M, Zhou Z, Liu S. A new method for preparing single-cell nuclear suspension of frozen spinal cord tissue. J Neurosci Methods. 2022 Mar 15;370:109490. doi: 10.1016/j.jneumeth.2022.109490. Epub 2022 Jan 25. PMID: 35090902.?
36.? Li J, Liu X, Wu H, Guo P, Li B, Wang J, Tian W, Chen D, Gao M, Zhou Z, Liu S. Identification of hub genes related to the innate immune response activated during spinal cord injury. FEBS Open Bio. 2022 Oct;12(10):1839-1856. doi: 10.1002/2211-5463.13472. Epub 2022 Sep 1. PMID: 36047918; PMCID: PMC9527585
37.? Wu H, Tong K, Liu X, Li J, Li X, Gao M, Tian W, Chen D, Zhou Z, Liu S. A comparison between two laminectomy procedures in mouse spinal cord injury on Allen's animal model. J Neurosci Methods. 2022 Feb 15;368:109461. doi: 10.1016/j.jneumeth.2021.109461. Epub 2021 Dec 24. PMID: 34958819.?
38.? Shangbin Cui#, Zhiyu Zhou#, Xizhe Liu, R. Geoff Richards, Mauro Alini,Songlin Peng, Shaoyu Liu, Xuenong Zou, Zhen Li, Sibylle Grad* Identification and Characterization of Serum microRNAs as Biomarkers for Human Disc Degeneration: An RNA Sequencing Analysis. diagnostics 2020, 10(12) , 1063
39.? Gao MM#, Su QN#, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY#, Zou NX#1. Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes. Eur Cell Mater. 2018 Jul 25;36:1-14. doi: 10.22203/eCM.v036a01.?
40.? Zhiyu Zhou#,，F(xiàn)uxin Wei#，Sheng Huang#,，Manman Gao,，Haisheng Li，Hans St?dkilde-J?rgensen,，Martin Lind,，Cody Bünger，Xuenong Zou(*),，InVivo Magnetic Resonance Imaging Evaluation of Porous Tantalum Interbody FusionDevices in a Porcine Spinal Arthrodesis Model,，Spine，2015.10.1,，40（19）：1471~8?
41.? Zhou, Zhiyu#,，Gao, Manman#，Wei, Fuxin#,，Liang, Jiabi,，Deng, Wenbin，Dai, Xuejun,，Zhou, Guangqian*,，Zou, Xuenong*，Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro,，Biomed Research International,，2014.3.5，8（1）：72~76?
42.? Gao M, Wang J, Jiang L, Pan X, Canavese F, Li Y, Wang W#, Zhou Z#, Zhu W#. Magnetic resonance imaging R2* sequences can better detect microstructural cartilage changes than T2 mapping in cynomolgus monkeys with limited knee kinematics: preliminary imaging findings. BMC Musculoskelet Disord. 2022 Sep 17;23(1):870. doi: 10.1186/s12891-022-05817-5. PMID: 36115988; PMCID: PMC9482308.
43.? Gao M, Guo P, Liu X, Zhang P, He Z, Wen L, Liu S, Zhou Z, Zhu W. Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing. BMC Mol Cell Biol. 2022 Jul 26;23(1):32. doi: 10.1186/s12860-022-00429-2. PMID: 35883033; PMCID: PMC9327421.
44.? Zhou, Zhiyang#,，Zhou, Zhiyu#,，Chen, Shaoming#,，Li, Haisheng，Zou, Lijin,，Ye, Jiacheng,，Ringgaard, Steffen，Bunger, Cody,，Zou, Xuenong*,，T1 rho-MR imaging technique to distinguish four-layered zonal structure of articular cartilage for detecting early-onset osteoarthritis，Journal of X-Ray Science and Technology,，2012.01.01,，20（4）：437~446?
45.? Chen, Da-Fu#，Zhou, Zhi-Yu#,，Dai, Xue-Jun#,，Gao, Man-Man，Huang, Bao-Ding,，Liang, Tang-Zhao,，Shi, Rui，Zou, Li-Jin,，Li, Hai-Sheng,，Bunger, Cody，Tian, Wei(*),，Zou, Xue-Nong(*),，Time-sequential changes of differentially expressed miRNAs during the process of anterior lumbar interbody fusion using equine bone protein extract, rhBMP-2 and autograft,，F(xiàn)RONTIERS OF MATERIALS SCIENCE,，2014.3.01，8（1）：72~86?
46.? Fuxin Wei#,，Rui Zhong#,，Zhiyu Zhou#，Le Wang,，Ximin Pan,，Shangbin Cui，Xuenong Zou,，Manman Gao,，Haixing Sun，Wenfang Chen,，Shaoyu Liu*,，In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey，BMC Musculoskelet Disord,，2014.10.9,，15（340）?
47.? Fuxin Wei#,，Le Wang#，Zhiyu Zhou#,，Rui Zhong,，Shaoyu Liu*，Shangbin Cui,，Ximin Pan,，Manman Gao，Cervical cage without plating in management of type II _ II A Hangman’s fracture combined with intervertebral disc injury,，BMC Musculoskeletal Disorders,，2015.10.6，16（285）?
48.? Fuxin Wei#,，Ximin Pan#,，Zhiyu Zhou#，Shangbin Cui,，Rui Zhong,，Le Wang，Manman Gao,，Ningning Chen,，Zijian Liang，Xuenong Zou,，Sheng Huang,，Shaoyu Liu(*)，Anterior-only stabilization using cage versus plating with bone autograft for the treatment of type II/IIA Hangman’s fracture combined with intervertebral disc injury,，J Orthop Surg Res,，2015.3.11，10（33）?
49.? Wei, F#,，Zhou, Z#,，Wang, L#，Liu, S,，Zhong, R,，Liu, X，Cui, S,，Pan, X,，Gao, M，Zhao, Y,，Biomechanical evaluation of monosegmental pedicle instrumentation in a calf spine model and the role of fractured vertebrae in screw stability,，BMC Vet Res . 2016 Mar 18;12:5，12：57?
50.? 周治宇,，鄒立津,，李海聲,，Cody Bünger，鄒學農(nóng)*,，骨蛋白提取物:新一代基于脫鈣骨基質(zhì)的骨修復(fù)材料,，中國科學:生命科學，2012.01.01,，（12）：974~985?
51.? 梁嘉碧,，李俊，汪婷,，梁雨虹,，鄒學農(nóng)，周光前,，周治宇*,，原位交聯(lián)透明質(zhì)酸水凝膠的制備及體外生物相容性研究，中國修復(fù)重建外科雜志,，2016.5.01,，（06）：767~771