個(gè)人簡介：
??中山大學(xué)附屬第七醫(yī)院科研中心研究員,，博士生導(dǎo)師。2013年獲得柏林洪堡大學(xué)細(xì)胞生物學(xué)博士學(xué)位（導(dǎo)師Walter Birchmeier院士/教授），2014-2020年先后在德國MDC分子醫(yī)學(xué)中心（合作導(dǎo)師Walter Birchmeier院士/教授）和英國Francis Crick研究所（合作導(dǎo)師Axel Behrens院士/教授）進(jìn)行博士后研究,，2021-2023年在英國倫敦腫瘤研究所（ICR）任職高級(jí)科學(xué)家（Staff Scientist）。2023年4月加入中山大學(xué)附屬第七醫(yī)院。在SCI期刊上發(fā)表論文共17篇，其中以第一/共同第一作者在Nature, EMBO J, Cancer Res及Cell Mol Life Sci等雜志上發(fā)表研究論文共8篇,。
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主要研究方向:
1. 腫瘤細(xì)胞譜系異質(zhì)性的時(shí)空演化及其調(diào)控機(jī)機(jī)制：
（1）腫瘤細(xì)胞譜系異質(zhì)性在耐藥和轉(zhuǎn)移過程中的時(shí)空演化；
（2）腫瘤細(xì)胞可塑性和干性對(duì)腫瘤譜系異質(zhì)性的調(diào)控,。
2. 腫瘤微環(huán)境（如腫瘤相關(guān)成纖維細(xì)胞和神經(jīng)細(xì)胞）的空間組織模式和功能解析,。
3. 小鼠腫瘤模型和腫瘤類器官模型建立和優(yōu)化。
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主要科研論文：
1. Lan L, Behrens A. Are there Specific Cancer Stem Cell Markers? Cancer Res 2023;83(2):170-172.
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2. Lan L, Evan T, Li H, Hussain A, Ruiz EJ, Zaw Thin M, Ferreira RMM, Ps H, Riising EM, Zen Y, Almagro J, Ng KW, Soro-Barrio P, Nelson J, Koifman G, Carvalho J, Nye EL, He Y, Zhang C, Sadanandam A, Behrens A. GREM1 is required to maintain cellular heterogeneity in pancreatic cancer. Nature 2022;607(7917):163-168.
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3. Li H#, Wang C#, Lan L#, Yan L#, Li W, Evans I, Ruiz EJ, Su Q, Zhao G, Wu W, Zhang H, Zhou Z, Hu Z, Chen W, Oliveira JM, Behrens A, Reis RL, Zhang C. METTL3 promotes oxaliplatin resistance of gastric cancer CD133+?stem cells by promoting PARP1 mRNA stability. Cell Mol Life Sci 2022;79(3):135. #Co-first author.
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4. Ruiz EJ, Lan L, Diefenbacher ME, Riising EM, Da Costa C, Chakraborty A, Hoeck JD, Spencer-Dene B, Kelly G, David JP, Nye E, Downward J, Behrens A. JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. JCI Insight 2021;6(13):e124985.
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5. Li H#, Wang C#, Lan L#, Wu W, Evans I, Ruiz EJ, Yan L, Zhou Z, Oliveira JM, Reis RL, Hu Z, Chen W, Behrens A, He Y, Zhang C. PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway. Front Cell Dev Biol 2021; 9:719192. #Co-first author.
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6. Li H#, Wang C#, Lan L#, Behrens A, Tomaschko M, Ruiz J, Su Q, Zhao G, Yuan C, Xiao X, Li B, Yan L, Wu W, Li W, Chen J, He Y, Zhang C. High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer. Aging (Albany NY) 2021;13(4):5197-5225. #Co-first author.
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7. Lan L, Holland JD, Qi J, Grosskopf S, Rademann J, Vogel R, Gy?rffy B, Wulf-Goldenberg A, Birchmeier W. Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice. EMBO J 2015;34(11):1493-508.
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8. Lan L, Han H, Zuo H, Chen Z, Du Y, Zhao W, Gu J, Zhang Z. Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis. Int J Cancer 2010;126(1):53-64.
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9. Lan L, Zhao F, Wang Y, Zeng H. The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: possible involvement of nuclear factor-kB-dependent pathway. Euro J Pharmacol 2007;555(2-3):83-92.
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個(gè)人郵箱:
lanlx5@mail.sysu.edu.cn