個(gè)人簡(jiǎn)介
? 鐘理，中山大學(xué)附屬第七醫(yī)院副研究員，碩士生導(dǎo)師,，深圳市高層次人才。主要研究方向：腫瘤轉(zhuǎn)移與微環(huán)境調(diào)控,、腫瘤耐藥與轉(zhuǎn)錄/表觀(guān)遺傳調(diào)控,。以第一/通訊作者發(fā)表研究論文共十二篇,，研究成果主要發(fā)表在Nature?Cell?Biology,、Science Advances,、Signal?Transduction?and?Targeted?Therapy、Advanced Science,、Cancer?letters等期刊,。
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教育工作經(jīng)歷
2021/8-至今，中山大學(xué)附屬第七醫(yī)院,，副研究員
2018/8—2021/7,，中山大學(xué)腫瘤防治中心，博士后
2013/09-2018/06,，中山大學(xué)腫瘤防治中心,，分子醫(yī)學(xué)，理學(xué)博士
2009/09-2013/06,，中山大學(xué)生命科學(xué)學(xué)院,，生物科學(xué)，理學(xué)學(xué)士
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研究?jī)?nèi)容
- 腫瘤轉(zhuǎn)移與微環(huán)境調(diào)控
腫瘤轉(zhuǎn)移是一個(gè)復(fù)雜的多步驟過(guò)程：腫瘤細(xì)胞從原發(fā)灶中脫離,，通過(guò)血液循環(huán)抵達(dá)遠(yuǎn)端轉(zhuǎn)移器官,，定植存活并增殖，最終形成腫瘤轉(zhuǎn)移灶,。我們主要研究腫瘤細(xì)胞與原位微環(huán)境以及轉(zhuǎn)移靶器官微環(huán)境的相互作用機(jī)制，鑒定在腫瘤轉(zhuǎn)移進(jìn)程中發(fā)揮重要作用的細(xì)胞亞群和分子,，從而建立靶向腫瘤轉(zhuǎn)移（腫瘤-微環(huán)境互作）的治療策略（Nat Cell Biol, 2020; Signal Transduct Target Ther; 2021; Adv Sci, 2023）,。
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- 腫瘤耐藥與表觀(guān)遺傳調(diào)控
腫瘤細(xì)胞可塑性的轉(zhuǎn)錄/表觀(guān)遺傳調(diào)控已受到廣泛關(guān)注，我們主要研究在腫瘤增殖及耐藥過(guò)程中發(fā)揮關(guān)鍵作用的轉(zhuǎn)錄/表觀(guān)遺傳調(diào)控因子,，明確其在相關(guān)疾病進(jìn)展中的作用機(jī)制以及靶向價(jià)值（Sci Adv, 2023; Cancer Letters, 2024）,。
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發(fā)表論文（#第一作者，*通訊作者）
(1)?? Li Zhong#, Jingxuan Wang#, Wanqi Chen#, Dongming Lv, Ruhua Zhang, Xin Wang, Cuiling Zeng, Xiaobo He, Lisi Zheng, Ying Gao, Shang Wang, Miao Li, Yuanzhong Wu, Junqiang Yin*, Tiebang Kang*, Dan Liao*. Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma. Science Advances（中科院一區(qū)）2023 Nov 24;9(47): eadi0889.
(2)?? Li Zhong#, Dan Liao#, Jingjing Li#, Wenqiang Liu, Jingxuan Wang, Cuiling Zeng, Xin Wang, Zhiliang Cao, Ruhua Zhang, Miao Li, Kuntai Jiang, Yi-Xin Zeng, Jianhua Sui*, Tiebang Kang*. Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes. Signal Transduction and Targeted Therapy （中科院一區(qū)）, 2021 Feb 11;6(1):59.
(3)?? Li Zhong#, Dan Liao#, Meifang Zhang, Cuiling Zeng, Xinchun Li, Ruhua Zhang, Haiqing Ma* Tiebang Kang*. YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma. Cancer Letters（中科院一區(qū),，ESI高被引）, 2019 Feb 1;442:252~261.
(4)?? Weijie Gao#, Jing Zhou#, Jintao Huang#, Zhiguang Zhang, Wanqi Chen, Ruhua Zhang, Tiebang Kang, Dan Liao*, Li Zhong*. Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. Cancer Letters（中科院一區(qū)）. 2024 Feb 7:586:216708
(5)?? Dan Liao#, Li Zhong#, Junqiang Yin#, Cuiling Zeng, Xin Wang, Xingchuan Huang, Jinna Chen, Hong Zhang, Ruhua Zhang, Xin-Yuan Guan, Xintao Shuai, Jianhua Sui, Song Gao, Wuguo Deng, Yi-Xin Zeng, Jing-Nan Shen*, Jian Chen*, Tiebang Kang*. Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma. Nature Cell Biology（中科院一區(qū)）, 2020 Jul;22(7):868-881.
(6)?? Cuiling Zeng#, Li Zhong#, Wenqiang Liu#, Yu Zhang, Xinhao Yu, Xin Wang, Ruhua Zhang, Tiebang Kang*, Dan Liao*. Targeting the lysosomal degradation of Rab22a-NeoF1 fusion protein for osteosarcoma lung metastasis. Advanced Science（中科院一區(qū)）, DOI: 10.1002/advs.202205483.
(7)?? Changlin Zhang#, Lixiang Liu#, Weizhao Li#, Mengxiong Li#, Xunzhi Zhang#, Chi Zhang, Huan Yang, Jiayuan Xie, Wei Pan, Xue Guo, Peng She*, Li Zhong*, Tian Li*. Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation. Cell Death & Disease（中科院一區(qū)）. 2023 Dec 16;14(12):837.
(8)?? Shang Wang#. Li Zhong#, Yin Li#, Desheng Xiao, Ruhua Zhang, Dan Liao, Dongming Lv, Xin Wang, Juanfei Wang; Xianbiao Xie; Jing Chen*; Yuanzhong Wu*, Tiebang Kang*. Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma. Theranostics（中科院一區(qū)）, 2019 Jun 9;9(15):4342-4353.
(9)?? Xinchun Li#, Li Zhong#, Zhuo Wang#, Huiming Chen, Dan Liao. Ruhua Zhang, Hongyu Zhang*, Tiebang Kang*. Phosphorylation of IRS4 by CK1 gamma 2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway. Theranostics（中科院一區(qū)）, 2018 Jun 7;8(13):3643-3653
(10) Dongming Lv#, Xiaoling Cao#, Li Zhong#, Yunxian Dong, Zhongye Xu, Yanchao Rong, Hailin Xu, Zhiyong Wang, Hao Yang, Rong Yin, Miao Chen, Chao Ke, Zhicheng Hu*, Wuguo Deng*, Bing Tang*. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing. Cell Reports Medicine（中科院一區(qū)）. 2023 Aug 15;4(8):101129.
(11) Miao Li#, Chang-Lin Zhang#, Di-Sheng Zhou#, Sze-Hoi Chan, Xue-Qi Liu, Shu-Na Chen, Zi-Yi Yang, Fei-Er Ju, Xiao-Yan Sang, Zi-Xuan Liu, Qiao-Xia Zhang, Yu-Ming Pan, Si-Si Deng, Xiao-Mei Wang, Li Zhong*, Xing-Ding Zhang*, Xin Du* Identification of COQ2 as a regulator of proliferation and lipid peroxidation through genome-scale CRISPR-Cas9 screening in myeloma cells. Br J Haematol （中科院二區(qū)）. 2024 Mar 10. doi: 10.1111/bjh.19375
(12) Shang Wang#, Yuqing Li#, Li Zhong#, Kai Wu, Ruhua Zhang, Tiebang Kang, Song Wu*, Yuanzhong Wu*. Efficient gene editing through an intronic selection marker in cells. Cellular and Molecular Life Sciences（中科院二區(qū)）,，2022, 79, 111.
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主持項(xiàng)目
（1）國(guó)家自然科學(xué)基金面上項(xiàng)目（2024-01至2027-12，在研）
（2）廣東省自然科學(xué)青年提升項(xiàng)目（2024-01至2026-12,，在研）
（3）深圳市醫(yī)學(xué)研究專(zhuān)項(xiàng)資金（2024-01至2026-12,，在研）
（4）廣東省自然科學(xué)面上項(xiàng)目（2022-11至2025-10，在研）
（5）深圳市自然科學(xué)基金面上項(xiàng)目（2022-10至2025-10,，在研）
（6）中山大學(xué)附屬第七醫(yī)院?jiǎn)?dòng)經(jīng)費(fèi)（2021-8至2024-8,，在研）
（7）博士后科學(xué)基金第13批特別資助（站中）（2020-07至2022-06,，結(jié)題）
（8）國(guó)家自然科學(xué)基金青年項(xiàng)目（2020-01至2022-12，結(jié)題）
（9）中山大學(xué)青年教師培育項(xiàng)目（2020-01至2022-12,，結(jié)題）
（10）博士后科學(xué)基金面上二等資助（2019-05至2021-05,，結(jié)題）
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聯(lián)系方式