個(gè)人簡(jiǎn)介：?
????? 盧盈穎，特聘副研究員,、碩士生導(dǎo)師,。香港大學(xué)醫(yī)學(xué)院細(xì)胞生物學(xué)博士,。目前實(shí)驗(yàn)室主要研究方向?yàn)樽允?/span>/細(xì)胞內(nèi)膜運(yùn)輸途徑在細(xì)胞應(yīng)激,，腫瘤生長(zhǎng)轉(zhuǎn)移,，及病毒感染中的作用機(jī)制,。作為（共同）第一作者/通訊作者在 Acta Pharmaceutica Sinica B,，Signal Transduction and Targeted Therapy,、Autophagy，Frontier in immunology,，FEBS Letter,，J Biomedical Science等著名學(xué)術(shù)期刊發(fā)表SCI論文10余篇。作為項(xiàng)目負(fù)責(zé)人承擔(dān)國(guó)家自然科學(xué)基金青年基金一項(xiàng),，廣東省前沿與關(guān)鍵技術(shù)創(chuàng)新專項(xiàng)資金-粵港聯(lián)合創(chuàng)新項(xiàng)目一項(xiàng),。目前獲得已授權(quán)的中國(guó)國(guó)家專利一項(xiàng)，深圳市科技創(chuàng)新委員會(huì)頒發(fā)的“省級(jí)科技項(xiàng)目獎(jiǎng)”一次,。
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主要發(fā)表論文：
1. Lu Y.Y.#, Liu F.#, Tong G.L.#, Qiu F., Song P. H., Wang X.L., Zou X.F., Wan D.Y., Cui M., Xu Y.S., Zheng Z.H., Hong P*. Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19. Signal Transduction and Targeted Therapy 6(1):107.
2. Tang, Y.C.# , Wang L.M.# , Yi, T., Xu, J., Wang, J.Q., Qin, J.J., Chen, Q.L., Yip, K.M., Pan, Y.H., Hong, P., Lu Y.Y.* Shen, H.M.,* Chen, H.B.* Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. Acta Pharmaceutica Sinica B (2021.05.13 Accepted) (* Corresponding author)
3. Wang X.W.*, Yang Y., Cai W. Q., Lu Y.Y.*. (2020) The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy. Front Immunol 2;11:574990.? (* Corresponding author)
4. Wang X.W.*, Sun Y., Peng X.C., Naqvi SMAS, Yang Y., Zhang J., Chen M.W.W., Chen Y., Chen H.Y., Yan H.Z., Wei G.L., Hong P., Lu Y.Y.*. (2020) The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target. Cancer Control 27(1):1073274820976664.? (* Corresponding author)
5. Chen C.#, Lu Y.Y.#, Siu H.M.#, Guan J.T., et al. Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis. Molecules, 2017, 22 (6) e891. (# equal contribution）
6. Lu Y.Y., Dong S.C., Hao B.X., et al. Vacuolin-1 Potently and Reversibly Inhibits Autophagosome-Lysosome Fusion by Activating RAB5. Autophagy, 2014, 10: 1-12.
7. Lu Y.Y., Chen T.S., Wang X.P., Qu J. L. The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells. FEBS Lett. 2010, 584: 4019-4026.
8. Lu Y.Y., Chen, T.S., Wang, X.P., Li L. Single cell analysis of dihydroartemisinin (DHA)-induced apoptosis through reactive oxygen species (ROS)-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques. J. Biomed. Opt. 2010, 15: 046028-1-16.
9. Lu Y.Y., Chen T.S., Qu J.L., Pan W.L., et al. Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma cells. J. Biomed. Sci. 2010, 16: 1-16.
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