個人簡介：
中山大學(xué)附屬第七醫(yī)院副研究員，碩士生導(dǎo)師,。2021年獲得中山大學(xué)腫瘤學(xué)博士學(xué)位,，并于2021/07-2023/11在中山大學(xué)附屬第一醫(yī)院進(jìn)行博士后研究工作。2024年1月通過博士后轉(zhuǎn)聘副研究員加入中山大學(xué)附屬第七醫(yī)院,。目前主持國自然青年科學(xué)基金1項(xiàng),，參與國自然面上科學(xué)基金和科技部重點(diǎn)研發(fā)項(xiàng)目各1項(xiàng)。先后在《Science Immunology》, 《Nature Chemical Biology》, 《Nature Communications》, 《Cancer Communications》, 《Advanced Science》等高影響因子學(xué)術(shù)期刊發(fā)表多篇學(xué)術(shù)成果,。
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教育工作經(jīng)歷：
2024/01-至今 中山大學(xué)附屬第七醫(yī)院 ?副研究員
2021/07-2023/11 中山大學(xué)附屬第一醫(yī)院? 臨床博士后?
2016/09-2021/06 中山大學(xué)腫瘤防治中心? 腫瘤學(xué)? 醫(yī)學(xué)博士
2011/09-2016/06 中山大學(xué)中山醫(yī)學(xué)院 ?臨床醫(yī)學(xué)? 醫(yī)學(xué)學(xué)士
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主要研究方向:
1. T細(xì)胞抗腫瘤免疫功能關(guān)鍵調(diào)控靶點(diǎn)鑒定及免疫治療技術(shù)開發(fā),。
2. 抑制性腫瘤免疫微環(huán)境形成機(jī)制及干預(yù)措施。
3. 惡性腫瘤發(fā)生發(fā)展新機(jī)制及治療策略,。
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經(jīng)費(fèi)項(xiàng)目
1. 國家自然科學(xué)基金青年項(xiàng)目（2024-01至2025-12,，在研，主持）,；
2. 國家自然科學(xué)基金面上項(xiàng)目（2022-01至2025-12,，在研，參與）,；
3. 國家重點(diǎn)研發(fā)計(jì)劃（2018-05至2022-12,，結(jié)題，參與）,。
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代表論文 (*為第一/共同第一作者,，#為通訊/共同通訊作者)：
1. Jie-Feng Yang*, Xudong Xing*, Li Luo*, Xin-Wei Zhou*, Jian-Xiong Feng, Kang-Bo Huang, Huashan Liu, Shanzhao Jin, Yi-Na Liu, Shi-Hui Zhang, Yi-Hui Pan, Bing Yu, Jin-Yu Yang, Yu-Lu Cao, Yun Cao, Cliff Y. Yang, Yuan Wang, Yuxia Zhang, Jiang Li, Xiaojun Xia, Tiebang Kang, Rui-Hua Xu, Ping Lan, Jun-Hang Luo, Hui Han#, Fan Bai#, Song Gao#. Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors. Science Immunology, 2023, 8(87): 0-eabq2424.
2. Jiefeng Yang*, Li Luo*, Chongyu Zhao*, Xiyuan Li*, Zimo Wang, Ziwei Zeng, Xin Yang, Xiaobin Zheng, Haiqing Jie, Liang Kang, Shujuan Li, Shuang Liu#, Chi Zhou#, Huashan Liu#. A Positive Feedback Loop between Inactive VHL-Triggered Histone Lactylation and PDGFRβ Signaling Drives Clear Cell Renal Cell Carcinoma Progression. Int J Biol Sci, 2022, 18(8): 3470-3483.
3. Li Luo*, Denghui Wei*, Yihui Pan*, Qiu-Xia Wang, Jian-Xiong Feng, Bing Yu, Tiebang Kang, Junhang Luo#, Jiefeng Yang#, Song Gao#. MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR. Cancer Communications, 2023, 43(7): 808-833.
4. Yihui Pan*, Guannan Shu*, Liangmin Fu*, Kangbo Huang*, Xinwei Zhou*, Chengpeng Gui, Huashan Liu, Xiaohan Jin, Minyu Chen, Pengju Li, Junjie Cen, Zihao Feng, Jun Lu, Zhenhua Chen, Jiaying Li, Quanhui Xu, Yinghan Wang, Hui Liang, Zhu Wang, Qiong Deng, Wei Chen, Junhang Luo#, Jiefeng Yang#, Jiaxing Zhang#, Jinhuan Wei#. EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1. Advanced Science, 2023, 10(11): 0-e2206792.
5. Yi-Na Liu*, Jie-Feng Yang*, Dai-Jia Huang*, Huan-He Ni, Chuan-Xia Zhang, Lin Zhang, Jia He, Jia-Mei Gu, Hong-Xia Chen, Hai-Qiang Mai, Qiu-Yan Chen, Xiao-Shi Zhang, Song Gao#, Jiang Li#. Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways. Frontiers in Immunology, 2020, 11(1906).
6. Jingtao Chen*, Jiefeng Yang*, Huan Li*, Zhongyuan Yang, Xing Zhang, Xiyuan Li, Jia Wang, Ying Zhang, Shuwei Chen#, Ming Song#. Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma. Molecular Oncology, 2021 Apr;15(4):866-886.
7. Yingjie Guo*, Huan Zhang*, Chen Yan, Birong Shen*, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, He Lv, Zhaoxia Wang, Yun Yuan, Jie-Feng Yang, Ya-Ting Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiaojiang Hao#, Junjie Hu#, Quan Chen#. Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Nature Chemical Biology, 2023 Apr;19(4):468-477.
8. Yu-Jie Li*, Yu-Lu Cao*, Jian-Xiong Feng*, Yuanbo Qi, Shuxia Meng, Jie-Feng Yang, Ya-Ting Zhong, Sisi Kang, Xiaoxue Chen, Lan Lan, Li Luo, Bing Yu, Shoudeng Chen, David C Chan, Junjie Hu, Song Gao#. Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nature Communications, 2019 Oct 29;10(1):4914.
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