個(gè)人簡(jiǎn)介：
曾樂立，2017年畢業(yè)于中山大學(xué)與美國(guó)St.John's大學(xué)聯(lián)合培養(yǎng)博士,，深圳市海外高層次B類人才,，現(xiàn)任中山七院樣本庫(kù)主任，副研究員,。課題組偏交叉學(xué)科前沿方向,，研究主要集中在抗腫瘤試劑設(shè)計(jì)及其等生物醫(yī)學(xué)材料在疾病斷與治療方面的應(yīng)用，以及探索腫瘤多藥耐藥新機(jī)制及其逆轉(zhuǎn)手段,，在Chem.Soc.Rev,、Adv.Mater、Small,、Mol.Cancer,、Sci.ChinaMater等期刊上發(fā)表SCI收錄論文40余篇，論文被引2000余次,；申請(qǐng)專利多項(xiàng),；負(fù)責(zé)國(guó)家、省,、市級(jí)等課題,，參與國(guó)家重點(diǎn)研發(fā)項(xiàng)目、重點(diǎn)項(xiàng)目等多項(xiàng),；任中國(guó)醫(yī)藥生物技術(shù)協(xié)會(huì)組織生物樣本庫(kù)分會(huì)會(huì)員,、中國(guó)化學(xué)會(huì)會(huì)員、廣東省藥學(xué)會(huì)生物醫(yī)藥分析專委會(huì)委員,、深圳市生物樣本專委會(huì)副主任委員,；兼任Fronters in pharmacology客座副主編等期刊編輯。
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學(xué)習(xí)經(jīng)歷：
2017/06-2013/08?? 中山大學(xué)?????????? 生物無機(jī)化學(xué) ?博士
2015/12-2017/01?? 美國(guó)圣約翰大學(xué)生物技術(shù)學(xué)院?? 聯(lián)合培養(yǎng)
2010/08-2013/06?? 湘潭大學(xué)???????????????? 碩士
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工作經(jīng)歷：
2019/08-至今?? ???中山七院 特聘副研究員
2019/07-2017/07? ?深圳大學(xué)醫(yī)學(xué)部博士后
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研究領(lǐng)域：
（1）腫瘤診療探針,；（2）腫瘤多藥耐藥逆轉(zhuǎn);（3）臨床樣本處理與大數(shù)據(jù)分析
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近期代表性論文：
1. Jia Li1, Leli Zeng1*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*,，Yihang Pan*. Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers. Advanced Materials (IF:30.849)，2022,，34 (1), 2100245.
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2. Yuzhi Xu, Si-Yang Liu, Yanfei Zhang, Hansu Ma, Huihui Yang, Yuchen Liu, Shuo Fang, Jing Zhao, Yunsheng Xu, Leli Zeng,* Zong Dai,* and Yihang Pan*. A Polymer as Drug Barrier against Systemic Toxicity for Cancer Starvation and Photodynamic Synergistic Therapy. Advanced Materials,，2022 (under review).
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3. Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Silpa Narayanan, Zi-Ning Lei, Qiu-Xu Teng, Leli Zeng*, Zhe-Sheng Chen*, “Overexpression of ABCG2 confers resistance to MLN7243, a ubiquitin-activating enzyme (UAE) inhibitor”, Frontiers in cell and developmental biology (IF: 6.684), 2021, 9, 1727.
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4. Leli Zeng, Kai Huang, Yilin Wan, Jing Zhang, Xikuang Yao, Chao Jiang, Jing Lin & Peng Huang*. “Programmable starving-photodynamic synergistic cancer therapy”. Science China Materials (IF: 8.273), 2020, 63, 611-619.
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5. Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao* and Zhe-Sheng Chen*, “The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials”, Chemical Society Reviews (IF: 54.564), 2017, 46, 5771-5804.
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6. Leli Zeng1, Gongcheng Ma1 (co-first author), Jing Lin, and Peng Huang*, “Photoacoustic probes for molecular detection: recent advances and perspectives”, Small (IF:13.281), 2018, 14, 1800782.
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7. Leli Zeng1, Gongcheng Ma1 (co-first author), Han Xu, Jing Mu, Fan Li, Xiaoting Gao, Zhuoting Deng, Junle Qu, Peng Huang and Jing Lin*, “In vivo chemoselective photoacoustic imaging of copper(II) in plant and animal subjects”, Small (IF:13.281), 2019, 15, 1803866.
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8. Leli Zeng1, Shi Kuang1 (co-first author), Guanying Li, Chengzhi Jin, Liangnian Ji and Hui Chao*, “A GSH-activatable ruthenium(II)-azo photosensitizer for two-photon photodynamic therapy”, Chemical Communications (IF:6.222), 2017, 53, 1977-1980.
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9. Leli Zeng1, Jia Li1 (co-first author), Chen Zhang, Yun-Kai Zhang, Wei Zhang, Juanjuan Huang, Charles R. Ashby Jr, Liangnian Ji, Zhe-Sheng Chen* and Hui Chao*, “An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms”. Chemical Communications (IF:6.222), 2019, 55, 3833-3836.
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10. Leli Zeng1, Yanyan Yuan1 (co-first author), Chao Jiang, Jing Mu, Fan Li, Yilin Wan, Han Xu, Junle Qu, Peng Huang and Jing Lin*, “A near-infrared turn-on probe for in vivo chemoselective photoacoustic detection of fluoride ions”, Dyes and Pigments (IF:4.889), 2019, 155, 408-414.
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學(xué)術(shù)兼職：
??? Frontiers系列期刊客座副主編，J.New Develop.Chem.客座編輯, Front.Pharmacol審稿編輯,；Med.Res.Rev,、Cancer Lett、Mol.Pharmaceut,、J.R.Soc.Interface,、Sci.Rep、Front.Pharmacol等SCI雜志通訊審稿人,。
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招生興趣：
???本課題組歡迎具有基礎(chǔ)醫(yī)學(xué),、化學(xué),、材料學(xué)、分子生物學(xué)等背景的同學(xué)前來深造與學(xué)習(xí),；本部門歡迎具有臨床樣本處理與大數(shù)據(jù)分析經(jīng)驗(yàn)的同學(xué)加盟七院工作,。
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聯(lián)系方式：
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