個(gè)人簡(jiǎn)介：
? ? ? ?現(xiàn)任中山大學(xué)附屬第七醫(yī)院副研究員,，碩士生導(dǎo)師,。于2016年獲得南方醫(yī)科大學(xué)病理生理學(xué)專業(yè)博士,。曾于2013-2017年在美國(guó)匹茲堡大學(xué)外科學(xué)系先后任Visiting Scholar和Research Associate,，并于2017-2020年在美國(guó)約翰斯·霍普金斯大學(xué)神經(jīng)學(xué)系任博士后,。目前主要研究方向包括：1.細(xì)胞外囊泡調(diào)控阿爾茲海默癥的發(fā)生發(fā)展機(jī)制研究,；2.神經(jīng)退行性疾病中,，細(xì)胞外囊泡與細(xì)胞死亡在其中發(fā)揮作用的分子機(jī)制研究,；3.發(fā)掘以細(xì)胞外囊泡為載體的相關(guān)疾病的新型生物標(biāo)記物,。共發(fā)表SCI論文11篇，以（共同）第一作者發(fā)表SCI論文6篇,，包括Journal of Extracellular Vesicles, Cell Death & Differentiation, Journal of Immunology等國(guó)際知名學(xué)術(shù)期刊,。曾榮獲國(guó)際細(xì)胞外囊泡協(xié)會(huì)2019年會(huì)的青年研究員獎(jiǎng)(ISEV2019 Young Investigator Award)。
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教育背景：
2011.09－2016.07,，南方醫(yī)科大學(xué),，病理生理學(xué),，博士?
2006.09－2011.07，廣州中醫(yī)藥大學(xué),，中醫(yī)學(xué),，學(xué)士
研究工作經(jīng)歷：
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2020.11－至今，中山大學(xué)附屬第七醫(yī)院,，科研中心,，副研究員
2017.11－2020.10，Johns Hopkins University,，Post-Doctoral Fellow??????
2015.10－2017.10,，University of Pittsburgh，Research Associate????????
2013.05－2015.09,，University of Pittsburgh,，Visiting Scholar??????????
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研究方向：
1、細(xì)胞外囊泡調(diào)控阿爾茲海默癥的發(fā)生發(fā)展機(jī)制研究
2,、神經(jīng)退行性疾病中,，細(xì)胞外囊泡與細(xì)胞死亡在其中發(fā)揮作用的分子機(jī)制研究
3、發(fā)掘以細(xì)胞外囊泡為載體的相關(guān)疾病的新型生物標(biāo)記物
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科研論文：
1. Zhigang Li, Mohammed Moniruzzaman, Raha M. Dastgheyb, Seung-Wan Yoo, Meina Wang, Hongbo Hao, Jia Liu, Patrizia Casaccia, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Barbara S. Slusher, Norman J. Haughey#. Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP. Journal of Extracellular Vesicles, 2020; 10(2):e12035. [IF: 25.841]
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2. Zhigang Li, Melanie J. Scott, Erica K. Fan, Yuehua Li, Jinghua Liu, Guozhi Xiao, Song Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang# and Jie Fan#. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death & Differentiation. 2016 Sep 1;23(9):1428-47 [IF: 15.828]
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3. Zhigang Li, Erica K. Fan, Jinghua Liu, Melanie J. Scott, Yuehua Li, Song Li, Wen Xie, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Ping Wang, and Jie Fan#. Cold-Inducible RNA-Binding Protein through TLR4 Signaling Induces Mitochondrial DNA Fragmentation and Regulates Macrophage Cell Death after Trauma. Cell Death & Disease. 2017 May 11;8(5):e2775. (2017) 8, e2775; doi:10.1038/cddis.2017.187 [IF: 8.469]
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4. Zhigang Li*, Yang Jiao*, Erica K. Fan, Melanie J. Scott, Yuehua Li, Song Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi#, and Jie Fan#. Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. The Journal of Immunology. 2017 Nov 1;199(9):3176-3186. [IF: 5.422] (*co-first author)
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5. Yang Jiao*, Zhigang Li*, Patricia A. Loughran, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi#, and Jie Fan#. Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. Journal of Leukocyte Biology. 2018 Feb;103(2):175-183. [IF: 4.962] (*co-first author)
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6. Zhigang Li, Melanie J. Scott, Tomasz Brzóska, Prithu Sundd, Yue-Hua Li, Timothy R. Billiar, Mark A. Wilson, Ping Wang, and Jie Fan#. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Military Medical Research. 2018 Jul 30;5(1):24. doi: 10.1186/s40779-018-0173-6. [IF: 3.329]
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7. Yang Xie, Meishu Xu, Meihong Deng, Zhigang Li, Pengcheng Wang, Songrong Ren, Yan Guo, Xiaochao Ma, Jie Fan, Timothy R. Billiar, Wen Xie. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock Induced Liver Injury. Hepatology. 2019 Sep;70(3):995-1010. doi: 10.1002/hep.30691.
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8. Camilo Rojas, Michal Sala, Ajit G. Thomas, Amrita Datta Chaudhuri, Seung‐Wan Yoo, Zhigang Li, Ranjeet P. Dash, Rana Rais, Norman J. Haughey, Radim Nencka, Barbara Slusher. A novel and potent brain penetrant inhibitor of extracellular vesicle release. British Journal of Pharmacology. 2019 Oct;176(19):3857-3870. doi: 10.1111/bph.14789.
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9. Xiaojuan Chai, Yan Guo, Mengxi Jiang, Bingfang Hu, Zhigang Li, Jie Fan, Meihong Deng, Timothy R. Billiar, Heidi Kucera, Nilesh W. Gaikwad, Meishu Xu, Peipei Lu, Jiong Yan, Haiyan Fu, Youhua Liu, Lushan Yu, Min Huang, Su Zeng, and Wen Xie. Oestrogen sulfotransferase ablation sensitizes mice to sepsis. Nature Communication. 2015 Aug 10;6:7979.
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