個(gè)人簡(jiǎn)介：
現(xiàn)任中山大學(xué)附屬第七醫(yī)院副研究員,，碩士生導(dǎo)師。于2016年獲得香港中文大學(xué)病理解剖及細(xì)胞學(xué)專業(yè)博士,。曾于2016-2019年在香港中文大學(xué)病理解剖學(xué)及細(xì)胞學(xué)系任博士后, 2020年8月加入中山大學(xué)附屬第七醫(yī)院科研中心任職。目前主要研究方向包括：1.??表觀遺傳修飾在癌癥發(fā)生發(fā)展中作用機(jī)制,；2.??肝癌中基因組,，轉(zhuǎn)錄組，表觀遺傳組和免疫微環(huán)境的異質(zhì)性,；3.??突變基因與異常表達(dá)的蛋白質(zhì),，非編碼RNA等在癌癥發(fā)生發(fā)展的作用機(jī)制及臨床應(yīng)用。目前研究成果主要發(fā)表在Gastroenterology, Hepatology等雜志上,。
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教育背景：
2004/09-2008/06? 中山大學(xué) ??生物技術(shù) ??學(xué)士
2011/08-2016/12? 香港中文大學(xué)? 病理解剖及細(xì)胞學(xué)系?? 博士
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工作經(jīng)歷：
2010/10-2011/07? 香港中文大學(xué)? 病理解剖及細(xì)胞學(xué)系 研究助理
2016/01-2019/10? 香港中文大學(xué)? 病理解剖及細(xì)胞學(xué)系 博士后
2020/08-今????? 中山大學(xué)附屬第七醫(yī)院 副研究員 碩士生導(dǎo)師
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主要研究方向:
- 表觀遺傳修飾在癌癥發(fā)生發(fā)展中作用機(jī)制,；
- 肝癌中基因組，轉(zhuǎn)錄組,，表觀遺傳組和免疫微環(huán)境的異質(zhì)性；
- 突變基因與異常表達(dá)的蛋白質(zhì),，非編碼RNA等在肝癌發(fā)生發(fā)展的作用機(jī)制及臨床應(yīng)用
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科研論文：
1.? Ding X #, He M #, Chan AW, Song QX, Sze SC, Chen Hui, Man MK, Man K, Chan SL, Lai PB, Wang X, Wong N. (2019). Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas. Gastroenterology 157,1630–1645; (# co-first author)
2.? Chen H #, Gao F #, He M # , Ding X, Wong AM, Sze SC, Yu AC, Sun TT, Chan AW, Wang X, Wong N. (2019). Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms. Hepatology 70, 1011-1025. (# co-first author)
3.??? He M #, Qin H #, Poon TC #, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N. (2015). Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs. Carcinogenesis 36, 1008-1018. (# co-first author)
4.??? Leung WK #, He M #, Chan AW, Law PT, Wong N. (2015). Wnt/beta-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Cancer Letters 362, 97-105. (# co-first author)
5.??? Lai KP, Chen JW, He M, Ching AK, Lau C, Lai PB, To KF, Wong N. (2014). Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma. Int J Cancer 135, 1790-1799.
6.??? Lau CC, Sun TT, Ching AK, He M, Li JW, Wong AM, Co NN, Chan AW, Li PS, Lung RW, Tong JH, Lai PB, Chan HL, To KF, Chan TF, Wong N. (2014). Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell 25, 335-349.
7.??? Law PT, Qin H, Ching AK, Lai KP, Co NN, He M, Lung RW, Chan AW, Chan TF, Wong N. (2013). Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma. J Hepatol 58, 1165-1173.
8.? Jiang L, Lin C, Song L, Wu J, Chen B, Ying Z, Fang L, Yan X, He M, Li J, Li M. (2012). MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-kappaB/IkappaBalpha negative feedback loop. J Clin Invest 122, 33-47.
9.??? Leung WK, Ching AK, Chan AW, Poon TC, He M, Wong AS, To KF, Wong N. (2011). A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility. Oncogene 30, 4464-4475.
10. ?Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, Yuan J, Cai JC, He M, Wang L, Zeng M, Cheng SY, Li M (2010). Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway. Am J Pathol 176, 699-709.
11.? Li M, Li J, Ding X, He M, and Cheng SY. (2010). microRNA and cancer. AAPS J 12, 309-317.
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