個(gè)人簡介:
鄧宇斌,上海交通大學(xué)醫(yī)學(xué)院博士,,1998-2000法國巴黎第七大學(xué)Sanit-Louis醫(yī)學(xué)院博士后,師從法國科學(xué)院院士E-GLuckman教授從事血液遺傳病的基因治療,,2010-2012美國Utah of University 醫(yī)學(xué)院外科實(shí)驗(yàn)室副研究員,,2018年美國Johns-Hopkins醫(yī)院骨科實(shí)驗(yàn)室高級訪問學(xué)者,。曾任中山醫(yī)學(xué)院病理生理學(xué)教研室主任,,干細(xì)胞中心副主任,,中山大學(xué)附屬第一醫(yī)院轉(zhuǎn)化醫(yī)學(xué)中心副主任,任中國病理生理免疫學(xué)會副主任委員2屆,,現(xiàn)任廣東省醫(yī)師協(xié)會神經(jīng)修復(fù)學(xué)會常委,,廣州市博士創(chuàng)新研究會常務(wù)理事,廣東省中西醫(yī)結(jié)合亞健康專業(yè)委員會常委,,國家自然科學(xué)基金及教育部博士點(diǎn)基金評審專家,,廣東省自然科學(xué)基金,北京市自然科學(xué)基金等評審專家,《中國康復(fù)醫(yī)學(xué)雜志》和《中華醫(yī)學(xué)雜志》編委,,《Biomaterials》和《Brain Research》審稿專家,。主持和承擔(dān)6項(xiàng)國家自然科學(xué)基金和其他省部級項(xiàng)目(省重點(diǎn)項(xiàng)目,重大專項(xiàng),,省部產(chǎn)學(xué)研)15余項(xiàng),已發(fā)表論文100多篇,;作為通訊作者發(fā)表了SCI論文40余篇,,IF5分以上論文8篇,IF10分以上論文3篇,,如Biomaterials,,Critical Care Medicine,CHEM COMMUN,,Biomacromolecules, Stem cell and Development?等,,總影響因子170多分。獲得國家發(fā)明專利授權(quán)3項(xiàng),,國家及省部級科研成果獎勵6項(xiàng),,1998年獲上海市科技進(jìn)步二等獎(主要完成人)一項(xiàng)。2002年獲廣東省科技進(jìn)步二等獎(第一完成人),,2007年獲南粵優(yōu)秀論文創(chuàng)新二等獎,,2010年獲《Brain Research》引用最多獎,2018年獲廣東省科技進(jìn)步二等獎(第一完成人),。主編《醫(yī)學(xué)科研概論》,、《病理生理學(xué)》等論著。曾任中華醫(yī)學(xué)獎評委,、廣東省科技獎評委,。主持國家級繼續(xù)教育項(xiàng)目“轉(zhuǎn)化醫(yī)學(xué)前沿進(jìn)展”。
從事轉(zhuǎn)化醫(yī)學(xué)研究近30年,,致力于造血干細(xì)胞移植免疫,、骨髓間質(zhì)干細(xì)胞免疫原性及MSCs誘導(dǎo)分化為神經(jīng)元治療中樞神經(jīng)神經(jīng)損傷性疾病等方面的研究,在病理生理學(xué)科領(lǐng)域內(nèi)有一定的知名度,。
長期招聘醫(yī)學(xué),,生物學(xué)、醫(yī)學(xué)材料(納米材料及水凝膠)等專業(yè)畢業(yè)的博士后,,先后指導(dǎo)四位博士后,,兩位獲得中國博士后基金,一位獲得2019年國家自然青年基金一項(xiàng),。獲得2019深圳科創(chuàng)委面上項(xiàng)目一項(xiàng),。
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教育背景:
1991/9–1994/6,上海第二醫(yī)科大學(xué),臨床免疫學(xué),,博士
1998/6-2000/6,,法國巴黎第七大學(xué),Saint-Louis醫(yī)學(xué)院(師從法國科學(xué)院院士E.G luckman教授),,博士后
2016/8-2016/10,,美國Johns-Hopkins大學(xué),Johns-Hopkins Hospital,,高級訪問學(xué)者
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研究工作經(jīng)歷:
1994/7-1996/7,,中山醫(yī)科大學(xué),博士后,,合作導(dǎo)師:李樹濃
1996/8-1998/5,,中山醫(yī)科大學(xué),中山醫(yī)學(xué)院病理生理學(xué)教研室,,副教授,、碩士生導(dǎo)師
1998/6-2000/6,法國巴黎第七大學(xué),,Saint-Louis醫(yī)學(xué)院(師從法國科學(xué)院院士E.G luckman教授),,博士后
2000/7-2001/11,中山醫(yī)科大學(xué),,中山醫(yī)學(xué)院病理生理學(xué)教研室,,副教授、碩士生導(dǎo)師
2001/12-2004/8,,中山大學(xué),,中山醫(yī)學(xué)院病理生理學(xué)教研室,教授,、教研室主任
2004/9-2010/9,,中山大學(xué),中山醫(yī)學(xué)院病理生理學(xué)教研室,,教授,、博士生導(dǎo)師
2010/10-2012/6,University of Utah School of Medicine,,外科實(shí)驗(yàn)室,,副研究員
2012/7-2017/12,中山大學(xué),,附屬第一醫(yī)院轉(zhuǎn)化醫(yī)學(xué)研究中心副主任,,教授、博士生導(dǎo)師
2017/12至今,,中山大學(xué),,附屬第七醫(yī)院骨科與神經(jīng)修復(fù)中心,,教授、博士生導(dǎo)師?
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研究方向:
1.?干細(xì)胞與生物材料聯(lián)合治療脊髓損傷
2. 干細(xì)胞的誘導(dǎo),、分化為神經(jīng)元的研究
3. 干細(xì)胞的體內(nèi)移植影像示蹤與在體研究
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科研立項(xiàng):
1. 國家自然科學(xué)基金面上項(xiàng)目,,82071362,星形膠質(zhì)細(xì)胞向A1型極化釋放C3通過下調(diào)UCHL1抑制qNSC激活對脊髓神經(jīng)再生的阻抑機(jī)制研究,,2021/01-2024/12,,55萬元,在研,,主持,。
2.?國家自然科學(xué)基金面上項(xiàng)目,81571105,,納米基因載體RGD-DMAPA-Amyp負(fù)載HIF-1α靶向遞送至缺血性腦卒中損傷內(nèi)皮細(xì)胞促血管新生,,2016/01-2019/12,,68萬元,,已結(jié)題,主持,。
3.?國家自然科學(xué)基金面上項(xiàng)目,,30973093,MSCs在中樞神經(jīng)損傷模型中向神經(jīng)元樣細(xì)胞功能分化的在MRI示蹤研究,,2009/01-2011/12,,33萬元,已結(jié)題,,主持,。
4. 深圳市科創(chuàng)委員會基礎(chǔ)研究面上項(xiàng)目,3D打印仿生脊髓支架聯(lián)合ADSCs誘導(dǎo)神經(jīng)再生促進(jìn)SCI功能恢復(fù)及機(jī)制研究,,2021.8-2024.8,,30萬元,在研,,主持
5.?深圳市科創(chuàng)委員會基礎(chǔ)研究面上項(xiàng)目,,JCYJ20190809165201646,阻斷脊髓損傷腦脊液抑制因子恢復(fù)UCHL1激活內(nèi)源NSCs促SCI修復(fù)的機(jī)制研究,,2020.1-2023.12,,10萬元,在研,,主持
6. 廣東省自然基金,,2015A030313186,新型納米?;蜉d體遞送HIF-1α促進(jìn)腦卒中損傷血管新生的機(jī)制研究,,2015/08-2018/08,,10萬元,已結(jié)題,,主持,。
7. 廣東省自然科學(xué)基金重點(diǎn)項(xiàng)目,S2013020012818,,智能水凝膠控釋Lingo-1RNAi促進(jìn)脊髓損傷修復(fù)作用研究,,2014/10-2016/10,30萬元,,已結(jié)題,,主持。
8. 廣東省-教育部產(chǎn)學(xué)研課題,,2012B091100457,,應(yīng)用智能靶向型納米粒包裹中藥糖視明緩釋新技術(shù)的研發(fā),2013/01-2015/12,,30萬元,,已結(jié)題,主持,。
9. 中山大學(xué)博士培養(yǎng)質(zhì)量研究項(xiàng)目,,醫(yī)科博士生科研創(chuàng)新思維培養(yǎng)及如何高質(zhì)量選題和開題,2019/1-2019/12,,5萬元,,進(jìn)行中,主持,。
10. 指導(dǎo)博士后劉凱清獲得2019年國家自然科學(xué)基金青年基金:TGF-β1/ActivinA誘導(dǎo)miR-124-3p差異表達(dá)促進(jìn)ADSCs轉(zhuǎn)分化形成功能性神經(jīng)元修復(fù)脊髓損傷的機(jī)制研究,。?
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發(fā)表論著:
1.? Xuhong Mao#, Lingli Long#, Juncheng Shen, Kunhua Lin, Lin Yin, Juzhen Yi, Li-Ming Zhang,* David Y. B. Deng*?and? Liqun Yang. Nanoparticles composed of the tea polysaccharide-complexed cationic vitamin B 12-conjugated glycogen derivative. Food Funct.2021(IF=5.391)
2.? Lingli Long#, Lingna Deng#, Liqin Wang, Shihong Wen, Liang Luo, Liqun Liang, Lu Ding, Jianfeng Wu, Zhizhong Ye*,and David Y. B. Deng*. P-Selectin-Based Dual-Model Nanoprobe Used for the Specific and Rapid Visualization of Early Detection toward Severe Acute Pancreatitis in Vivo. ACS Biomater. Sci. Eng. 2020. (IF=4.471)
3. ?Lingna Deng#, Fang Zhang, Yanlin Wu, JiahaoLuo, Xuhong Mao, Lingli Long, Maling Gou. Liqun Yang*, David Y. B. Deng*.? RGD-Modified Nanocarrier-Mediated Targeted Delivery of HIF-1α-AA Plasmid DNA to Cerebrovascular Endothelial Cells for Ischemic Stroke Treatment. ACS Biomater. Sci. Eng. 2019, 5, 11, 6254-6264(?IF=4.471 )
4. ?Zhiming Peng#, Xiang Li#, Kai Zhu, Lingli Long, Xiaoyang Zhao, Qingui Chen,David Y. B. Deng*,Yong Wan*, Inhibition of Notch1 signaling promotes neuronaldifferentiation and functional recovery in spinal cord injury through suppression ofactivation of RhoA,Journal of neurochemistry (JNC-2019-0308), 2019.?(IF=5.372)
5. ?Lingli Long#, Minghua Lai#,Xuhong Mao, Jiahao Luo,3Xin Yuan,Li-Ming Zhang,ZunfuKe, Liqun Yang*,David YB Deng*.Investigation Of Vitamin B12-Modified Amphiphilic Sodium Alginate Derivatives For Enhancing The Oral Delivery Efficacy Of Peptide Drugs.International Journal of Nanomedicine,2019:14 7743–7758 (IF=6.401)
6. ?Xuan Liu#, Jie Tao#, Jinlu Liu#, XinXu, Jiumeng Zhang, Yulan Huang, Yuwen Chen, Jing Zhang, David Y. B. Deng, Maling Gou*, Yuquan Wei*. 3D Printing Enabled Customization of Functional Microgels. ACS Applied Materials & Interfaces, 2019,11(13):12209-12215 (IF=9.220)
7. ?Xiaoyang Zhao#, ZhimingPeng#, Lingli Long, Ningning Chen, HaichongZheng,David Y. B. Deng*, Yong Wan*, Lentiviral vector delivery of short hairpin RNA to NgR1promotes nerve regeneration and locomotor recovery in injured rat spinal cord, ScientificReports , 2018, 8:5447, 2018, 8: 5447 (IF=4.372)
8. ?Ruirui Yang(#), Caixia Xu(#), Tao Wang, Yuanqi Wang, Jingnan Wang, Daping Quan (*) and David Y. B. Deng (*). PTMAc-PEG-PTMAc hydrogel modified by RGDC and hyaluronic acid promotes neural stem cells' survival and differentiation in vitro. RSC Advances. 2017,7,41098-41104.(共同通訊作者)
9. ?Yingling Miao(#), Ruirui Yang, David YB Deng (*), and Li-Ming Zhang (*), 1Poly(L-lysine) modified zein nanofibrous membranes as efficient scaffold for adhesion, proliferation and differentiation of neural stem cells.? RSC ADV, 2017.7.17711-17719.(共同通訊作者)
10. ?Jingnan Wang(#), Jiayun Tan(#), Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li?ming Zhang, Banghao Zhu, Liqun Yang(*)?and David Y. B. Deng(*) . Enhancement of scutellarin oral delivery efcacy by vitamin B12-modifed amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy . J Nanobiotechnology. 2017 Mar 01 ;15(1).(共同通訊作者)
11. ?Minghua Lai(#), Jingnan Wang(#), Jiayun Tan, Jiahao Luo, Li-Ming Zhang,? David Y. B. Deng(*), Liqun Yang(*). Preparation, complexation mechanism and properties of? nano-complexes of Astragalus polysaccharide and amphiphilic? chitosan derivatives . Carbohydrate Polymers 2017.03.04,161:261-269.
12. ?Ningning Chen(#), Jingsheng Cen, Jingnan Wang, Gangjian Qin, Lingli Long, Le Wang, Fuxin Wei,? Qingfeng Xiang, David Deng(*), yong wan(*), Targeted inhibition of LINGO-1 in transplanted neural stem cells promotes neuronal differentiation and functional recovery in rats subjected to spinal cord injury.? Critical Care Medicine , 2016 Mar;44(3):e146-57.(共同通訊作者)
13. ?Jue? Wang(#) , Zhizhong Ye(#); Shuhui Zheng; Luming Chen; Yong Wan(*) ; Yubin Deng(*); Ruirui Yang. Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/ progenitor cells into neurons? Brain Research? 2016 Mar 1;1634:34-44.?(共同通訊作者)
14. ?Lingli Long(#), Jingnan Wang(#), Ningning Chen, Shuhui Zheng, Lanying Shi, Yuxia Xu, Canqiao Luo(*), Yubin Deng(*).Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IκB-α/NF-κB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats. J Med Food. 2016 Jun;19(6):528-534.?(共同通訊作者)
15. ?Huang C, Zheng H, He W, Lu G, Li X, Deng Y(*), Zeng M(*). Ghrelin ameliorates the human alveolar epithelial A549 cell apoptosis induced by lipopolysaccharide. Biochem Biophys Res Commun. 2016 May 20;474(1):83-90.(共同通訊作者)
16. ?Fang Liu(#),Jingnan Wang,Qingyun Cao,Haidong Deng,guang shao,David Y. B. Deng(*)andWuyi Zhou(*). One-step synthesis of magnetic hollow mesoporous silica (MHMS) nanospheres for drug delivery nanosystems via electrostatic self-assembly templated approach.?Chem Commun (Camb).??2015? 11;51(12):2357-60.?
17. ?He T(#),?Wang J(#),?Huang P,?Zeng B,?Li H,?Cao Q,?Zhang S,?Luo Z,?Deng DY(*),?Zhang H(*),?Zhou W(*). Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing.?Colloids Surf B Biointerfaces.?2015 Jun 1;130:278-86.?(共同通訊作者)
18. ?Peilin Huang(#), Jingnan Wang(#), Shuting Lai, Fang Liu, yubin Deng (*), Wuyi Zhou(*). Surface modified titania nanotubes containing antibacterial drugs for controlled delivery nanosystems with high bioactivity. Journal of Materials Chemistry B. 2014,2, 8616-8625.?(共同通訊作者)
19. ?Fang Liu(#), Hongwu Zhang, Qingyun Cao, yubin Deng(*), Wuyi Zhou(*). High-efficiency loading in small mesopores (2–3 nm) forming a matrix type controlled drug delivery nanosystem . RSC Advances. 2014.4(17).8918-8921.(共同通訊作者)
20. ?Zhang HW(#), Wang LQ, Xiang QF, yubin Deng(*). Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis. Biomaterials. 2014.35(1).356-67(IF:8.55).
21. ?Liang X(#),?Ren X,?Liu Z,?Liu Y,?Wang J,?Wang J,?Zhang LM,?Deng DY(*),?Quan D,?Yang L(*). An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives.?Int J Nanomedicine.?2014 31;9:419-35.(共同通訊作者)
22. ?Cen JS(#), Wu HF, Wang J, Ren XY, Zhang HW, Wang JN, Deng YB(*), Wan Y(*). Local injection of lentivirus encoding LINGO-1 shRNA promotes functional recovery in rats with complete spinal cord transaction. Spine. 2013.38(19).1632-1639.?(共同通訊作者)
23. ?Wu HF(#), Cen JS, Zhong Q, Chen LM, Wang J, Yong Wan(*), yubin Deng(*). The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127. Biomaterials. 2013.34(6).1686-700.(共同通訊作者)
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專利:
1.鄧宇斌,;全大萍,;楊瑞瑞. 一種聚合物、含有該聚合物的水凝膠及其應(yīng)用,,發(fā)明專利.2018-08-28
1.鄧宇斌.?一種修復(fù)中樞神經(jīng)損傷的藥物組合物.?發(fā)明專利. 2007-10-03
2.鄧宇斌,;吳洪福;萬勇.?用于修復(fù)神經(jīng)損傷的水凝膠包裹慢病毒Lingo-1RNAi復(fù)合物及其制備方法.?發(fā)明專利.2013-12-04?
個(gè)人郵箱:
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