個人簡介：
中山大學(xué)碩士生導(dǎo)師,，副研究員，中山大學(xué)海外高層次引進人才,，廣東省精準醫(yī)學(xué)應(yīng)用學(xué)會精準檢測分會常務(wù)委員,。博士畢業(yè)于中山大學(xué)中山醫(yī)學(xué)院病原生物學(xué)專業(yè),，曾任杜克大學(xué)醫(yī)學(xué)院高級研究員。主要研究方向：腫瘤代謝免疫以及耐藥的分子機制研究,。主持省部級以上課題4項,，出版學(xué)術(shù)專著1部（獨立著作）,，獲得廣東省科學(xué)技術(shù)獎勵二等獎1項。已申請美國PCT專利1項,，中國發(fā)明專利4項（已授權(quán)2項）,。累積發(fā)表SCI論文30余篇，包括Cell Metabolism,，Nature Cell Biology,，Cell Discovery， Molecular Cell,，JOURNAL OF EXPERIMENTAL MEDICINE,，STAR Protocols等學(xué)術(shù)期刊。
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著作,、論文,、成果：
1. Che-Chia Hsu, Guihua Wang, Chien-Feng Li, XIAN ZHANG, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gui, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhong-zhu Chen, Ming Chen, Andrew Armstrong, Jiaoti Huang, Hong-yu Li, and Hui-Kuan Lin. IMPA1-derived inositol maintains stemness in castration resistant prostate cancer via IMPDH2 activation. J Exp Med. 2024 Nov 4;221(11):e20231832.
2. Chen T, Lin HK. Protocol to analyze the role of various metabolites in impacting global RNA 5-methylcytosine levels in cultured cells by dot blot. STAR Protocols 2024 Jan 4;5(1):102815.
3. Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Tingjin Chen, Xinbing Yu, Yan Huang, Qingxia Xu. ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells. PLoS Negl Trop Dis 17(11): e0011727.
4. Chen T, Xu ZG, Luo J, Manne RK, Wang Z, Hsu CC, Pan BS, Cai Z, Tsai PJ, Tsai YS, Chen ZZ, Li HY, Lin HK. NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance. Cell Metab. 2023 Aug 3:S1550-4131(23)00267-X.
5. Li S, Chen X, Zhou J, Xie Z, Shang M, He L, Liang P, Chen T, Mao Q, Liang C, Li X, Huang Y, Yu X. Amino acids serve as an important energy source for adult flukes of Clonorchis sinensis. PLoS Negl Trop Dis. 2020 Apr 30;14(4):e0008287.
6. Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, Peng D, Xu X, Lin HK. Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Cell Discov. 2020 Mar 24;6:15.
7. Hsu CC, Zhang X, Wang G, Zhang W, Cai Z, Pan BS, Gu H, Xu C, Jin G, Xu X,
Manne RK, Jin Y, Yan W, Shao J, Chen T, Lin E, Ketkar A, Eoff R, Xu ZG, Chen ZZ,
Li HY, Lin HK. Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK. Mol Cell. 2021 Sep 16;81(18):3803-3819.e7.
8. Kant R, Manne RK, Anas M, Penugurti V, Chen T, Pan BS, Hsu CC, Lin HK.
Deregulated transcription factors in cancer cell metabolisms and reprogramming.
Semin Cancer Biol. 2022 Nov;86(Pt 3):1158-1174.
9. Wang N, Zhang Z, Huang L, Chen T, Yu X, Huang Y. Current status and progress
in the omics of Clonorchis sinensis. Mol Biochem Parasitol. 2023 Apr 29;255:111573.
10. Chen T#, Jiang H#, Sun H, Xie Z, Ren P, Zhao L, Dong H, Shi M, Lv Z, Wu Z, Li X, Yu X, Huang Y, Xu J. Sequence analysis and characterization of pyruvate kinase
from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective
efficacy against clonorchiasis. Parasit Vectors. 2017 Nov 9;10(1):557.
11. Tang Z#, Sun H#, Chen T#, Lin Z, Jiang H, Zhou X, Shi C, Pan H, Chang O, Ren P, Yu J, Li X, Xu J, Huang Y, Yu X. Oral delivery of Bacillus subtilis spores expressing cysteine protease of Clonorchis sinensis to grass carp (Ctenopharyngodon idellus): Induces immune responses and has no damage on liver and intestine function. Fish Shellfish Immunol. 2017 Mar 18;64:287-296.
12. Jiang H#, Chen T#, Sun H, Tang Z, Yu J, Lin Z, Ren P, Zhou X, Huang Y, Li X, Yu X. Immune response induced by oral delivery of Bacillus subtilis spores expressing enolase of Clonorchis sinensis in grass carps (Ctenopharyngodon idellus). Fish and Shellfish Immunology. 2017 Jan;60:318-325.
13. Chen W#, Ning D#, Wang X#, Chen T#, Lv X, Sun J, Wu D, Huang Y, Xu J, Yu X. Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. Parasit Vectors. 2015 Dec 21;8(1):647.
14. Yu J#,?Chen T#, Xie Z, Liang P, Qu H, Shang M, Mao Q, Ning D, Tang Z, Shi M, Zhou L, Huang Y, Yu X. Oral delivery of Bacillus subtilis spore expressing enolase of Clonorchis sinensis in rat model: induce systemic and local mucosal immune responses and has no side effect on liver function. Parasitol Res. 2015 Jul;114(7):2499-505.
15. Chen T#, Yu J#, Tang Z, Xie Z, Lin Z, Sun H, Wan S, Li X, Huang Y, Yu X, Xu J. Advanced Enzymology, Expression Profile and Immune Response of Clonorchis sinensis Hexokinase Shows Its Application Potential for Prevention and Control of Clonorchiasis. PLoS Negl Trop Dis. 2015 Mar 23;9(3):e0003641.
16. Chen T, Ning D, Sun H, Li R, Shang M, Li X, Wang X, Chen W, Liang C, Li W, Mao Q, Li Y, Deng C, Wang L, Wu Z, Huang Y, Xu J, Yu X. Sequence analysis and molecular characterization of Clonorchis sinensis hexokinase, an unusual trimeric 50-kDa glucose-6-phosphate-sensitive allosteric enzyme. PLoS ONE 9(9): e107940. ?
17. Chen T, Huang Y, Yu X. Serious challenge and thinking of clonorchiasis. Chin J Dis Control Prev. 2016,20(1):1-4,12. (in Chinese)
18. Chen T, Yu X. Pregnancy with listeria infection. Chin J Obstet Emerg. 2015 May,4(2):105-109. (in Chinese)
19. Tang Z#, Shang M#, Chen T, Ren P, Sun H, Qu H, Lin Z, Zhou L, Yu J, Jiang H, Zhou X, Li X, Huang Y, Xu J, Yu X. The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease. Parasit Vectors. 2016 Dec 19;9(1):648.
20. Li W#, Dong H#, Huang Y, Chen T, Kong X, Sun H, Yu X, Xu J. Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients. PLoS Negl Trop Dis. 2016 Jun 27;10(6):e0004806.
21. Zhou L, Shi M, Zhao L, Lin Z, Tang Z, Sun H, Chen T, Lv Z, Xu J, Huang Y, Yu
X. Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis. Parasit Vectors. 2017 Jun 17;10(1):295.
22. Shi M, Zhou L, Zhao L, Shang M, He T, Tang Z, Sun H, Ren P, Lin Z, Chen T, Yu
J, Xu J, Yu X, Huang Y. Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2+ dyshomeostasis in hepatocarcinoma PLC cells. PLoS Negl Trop Dis. 2017 Nov 10;11(11):e0006074.
23. Jia F, Li Y, Huang Y, Chen T, Li S, Xu Y, Wu Z, Li X, Yu X. Molecular characterization and expression of Rab7 from Clonorchis sinensis and its potential role in autophagy. Parasitol Res. 2013 Jul;112(7):2461-7.
24. Xu J, Wang L, Deng C, Hu X, Li R, Chen T, Ning D, Wu Y, Huang Y, Li X, Wu Z, Yu X, Li Y. The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection. Parasitol Res. 2014 Jan;113(1):149-55.
25. Ren M, He L, Huang Y, Mao Q, Li S, Qu H, Bian M, Liang P, Chen X, Ling J, Chen T, Liang C, Wang X, Li X, Yu X. Molecular characterization of Clonorchis sinensis secretory myoglobin: Delineating its role in anti-oxidative survival. Parasit Vectors. 2014 May 29;7:250.
26. Mao Q, Xie Z, Wang X, Chen W, Ren M, Shang M, Lei H, Tian Y, Li S, Liang P, Chen T, Liang C, Xu J, Li X, Huang Y, Yu X. Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates in?ammation signaling in human hepatic stellate cells. Parasitol Res. 2015 Feb;114(2):659-70.
27. Zhou L, Shang M, Shi M, Zhao L, Lin Z, Chen T, Wu Y, Tang Z, Sun H, Yu J, Huang Y, Yu X. Clonorchis sinensis lysophospholipase inhibits TGF-β1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2. Parasitol Res. Parasitol Res. 2016 Feb;115(2):643-50. doi: 10.1007/s00436-015-4782-7. ?
28. Wu Y, Li Y, Shang M, Jian Y, Wang C, Bardeesi AS, Li Z, Chen T, Zhao L, Zhou L, He A, Huang Y, Lv Z, Yu X, Li X. Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling. Parasit Vectors. 2017 Mar 16;10(1):147.
29. Wu Z, Tang Z, Shang M, Zhao L, Zhou L, Kong X, Lin Z, Sun H, Chen T, Xu J, Li X, Huang Y, Yu X. Comparative analysis of immune effects in mice model: Clonorchis sinensis cysteine protease generated from recombinant Escherichia coli and Bacillus subtilis spores. Parasitol Res. 2017 Jul;116(7):1811-1822.
30. Wang C, Lei H, Tian Y, Shang M, Wu Y, Li Y, Zhao L, Shi M, Tang X, Chen T, Lv Z, Huang Y, Tang X, Yu X, Li X. Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma. Parasit Vectors. 2017 May 25;10(1):262.
31. Zhao L, Shi M, Zhou L, Sun H, Zhang X, He L, Tang Z, Wang C, Wu Y, Chen T, Shang M, Zhou X, Lin Z, Li X, Yu X, Huang Y. Clonorchis sinensis adult-derived proteins elicit Th2 immune responses by regulating dendritic cells via mannose receptor. PLoS Negl Trop Dis. 2018 Mar 5;12(3):e0006251.
32. Sun H, Lin Z, Zhao L, Chen T, Shang M, Jiang H, Tang Z, Zhou X, Shi M, Zhou L, Ren P, Qu H, Lin J, Li ?X, Xu J, Huang Y, Yu X. Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate. Parasit Vectors. 2018 Mar 7;11(1):156.
33. 任鵬麗,陳庭金,黃艷,曾偉偉,余新炳. 草魚呼腸孤病毒HZ08株外衣殼蛋白VP4的節(jié)段克隆表達和免疫學(xué)分析[J]. 熱帶醫(yī)學(xué)雜志,2016,02:140-144+271.
34. 石夢辰,陳庭金,周麗娜,趙璐,任鵬麗,孫恒昌,林志鵬,黃艷,余新炳. 華支睪吸蟲severin蛋白對肝癌細胞SMMC-7402增殖、遷移及侵襲作用的初步研究[J]. 熱帶醫(yī)學(xué)雜志,2016,02:127-130+205+272.
35. 楊旭然,陳庭金,余新炳. 誘導(dǎo)型一氧化氮合酶與寄生蟲感染的研究進展[J]. 中國病原生物學(xué)雜志, 2016,09:855-857.
36. 侯珠秀,陳庭金,黃艷,余新炳. IL-25在寄生蟲感染性疾病中的研究進展[J]. 熱帶醫(yī)學(xué)雜志,2016,08:1086-1088.
37. 宛碩,黃艷,陳庭金,徐勁,余新炳. 巨噬細胞極化的研究進展[J]. 中國病原生物學(xué)雜志,2015,11:1051-1054.
38. 李然,余新炳,陳庭金,鄧傳歡,王樂旬,李文芳,黃艷,徐勁. 華支睪吸蟲鈣調(diào)理蛋白的克隆表達,、組織定位及功能的初步研究[J]. 中國病原生物學(xué)雜志,2013,05:411-416.
39. 孫恒昌,陳庭金,黃艷,徐勁,余新炳. 魚用疫苗研究進展[J]. 熱帶醫(yī)學(xué)雜志,2014,12:1651-1656.
40. 陳志文,馮姣,蔣敏敏,陳春梅,肖星,何婭,易修文,陳庭金,席麗艷. 構(gòu)建以eGFP為報告基因的畢赤酵母表達載體[J]. 皮膚性病診療學(xué)雜志,2016,03:152-155.
41.?王彩琴,雷華麗,田艷麗,尚梅,吳銀娟,李曄,陳庭金,黃艷,余新炳,李學(xué)榮. 華支睪吸蟲顆粒蛋白在蟲體及宿主中的表達[J]. 熱帶醫(yī)學(xué)雜志,2017,(04):413-415+434+408.
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專利:
1.?INHIBITION OF NSUN2 FOR THE TREATMENT OF CANCER,，申請時間2023年7月14日，Hui-Kuan Lin,Tingjin Chen,，美國,，專利申請?zhí)?/font>: 63/513,693.
2. 余新炳,周心怡,姜紅燁,唐澤麗,孫恒昌,黃艷,陳庭金,林志鵬,任鵬麗. 通用型淡水魚多克隆抗體及其制備與應(yīng)用[P]. 廣東：CN106565842A,2017-04-19.
3. 余新炳,任鵬麗,黃艷,陳庭金,唐澤麗,孫恒昌,林志鵬,姜紅燁,周心怡. 一種草魚出血病口服疫苗及其制備與應(yīng)用[P]. 廣東：CN105801707B, 2019-08-30.
4. 余新炳,孫恒昌,姜紅燁,周心怡,唐澤麗,林志鵬,黃艷,陳庭金. 一種淡水魚華支睪吸蟲囊蚴感染膠體金快速檢測試紙條及其制作方法[P]. 廣東：CN106771171A,2017-05-31.
5. 余新炳,唐澤麗,孫恒昌,姜紅燁,黃艷,陳庭金,林志鵬,周心怡. 魚華支睪吸蟲病口服疫苗及其制備與應(yīng)用[P]. 廣東：CN107266578B, 2021-05-07.
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專著:
陳庭金.華支睪吸蟲糖酵解關(guān)鍵酶己糖激酶的功能研究[M].北京：《中國學(xué)術(shù)期刊（光盤版）》電子雜志社有限公司,2024.（ISBN:978-7-499-01189-2, 入選“十三五”國家重點出版規(guī)劃項目——青年學(xué)者優(yōu)秀學(xué)術(shù)專著文庫）
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個人郵箱: