個(gè)人簡介:
中山大學(xué)附屬第七醫(yī)院副研究員,,碩士生導(dǎo)師,,深圳市高層次人才。主要研究方向:新型生物醫(yī)藥設(shè)計(jì)與抗腫瘤應(yīng)用及其腫瘤耐藥逆轉(zhuǎn)研究,。共發(fā)表論文近20篇,,其中以第一/通訊作者發(fā)表研究論文12篇,研究成果主要發(fā)表在Molecular Cancer,、Advanced Materials,、ACS Applied Materials & Interfaces、Inorganic Chemistry Frontiers,、Chemical Communications等期刊,,申請中國發(fā)明專利1項(xiàng)并獲得授權(quán)。目前主持國自然科學(xué)基金青年項(xiàng)目,、廣東省自然科學(xué)面上項(xiàng)目1項(xiàng),、深圳市面上項(xiàng)目1項(xiàng),參與國自然科學(xué)基金面上項(xiàng)目1項(xiàng),。
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教育背景:
2017/09-2020/06 中山大學(xué) ?生物無機(jī)化學(xué) ??博士
2014/09-2017/06 湘潭大學(xué)? 化學(xué)生物學(xué)? ???碩士
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工作經(jīng)歷:
2024/01-至今? 中山大學(xué),,附屬第七醫(yī)院,副研究員
2022/10-2023/12 中山大學(xué),,附屬第七醫(yī)院,,助理研究員
2020/09-2022/09 中山大學(xué),附屬第七醫(yī)院,,博士后
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主要研究方向:
1. 新型抗腫瘤藥物設(shè)計(jì)與抗腫瘤應(yīng)用研究
2. 工程化外泌體構(gòu)建與腫瘤精準(zhǔn)治療研究
3. 微生物耐藥與腫瘤多藥耐藥逆轉(zhuǎn)研究
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在研項(xiàng)目
(1)國家自然科學(xué)基金委員會,,國家自然科學(xué)基金青年項(xiàng)目,2024-01至2026-12,,30萬元, 在研,主持,。
(2)國家自然科學(xué)基金委員會,,面上項(xiàng)目,2023-01至2026-12,,53萬元,,在研,,參與,。
(3)廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究基金委員會,面上項(xiàng)目,,2023-01至2025-12,,10萬元,在研, 主持,。
(4)深圳市科技創(chuàng)新委員會,,面上項(xiàng)目,2022-10至2025-10,,15萬元,,在研,主持,。
(5)廣東省消化系統(tǒng)惡性腫瘤防治研究重點(diǎn)實(shí)驗(yàn)室2022年度開放基金,,5萬元,結(jié)題,,主持,。
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代表性論文 (1為第一/共同第一作者,*為通訊/共同通訊作者)
(1) Hongfa Wei1, Wenchao Li1, Leli Zeng, Ni Ding, Kuan Li, Hong Yu, Fei Jiang, Haofan Yin, Yu Xia, Cuncan Deng, Nan Cai, Xiancong Chen, Liang Gu, Huanjie Chen, Feiran Zhang*, Yulong He*, Jia Li*, Changhua Zhang*, OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway, Molecular Cancer, 2024. 中科院一區(qū) (IF=37.3)
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(2) Cuncan Deng1, Mingyu Huo1, Hongwu Chu1, Xiaomei Zhuang1, Guofei Deng, Wenchao Li, Hongfa Wei, Leli Zeng*, Yulong He, Huashan Liu, Jia Li*, Changhua Zhang*, Hengxing Chen*, Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote?gastric cancer progression, Molecular Cancer, 2024, 23(1): 49. 中科院一區(qū) (IF=37.3)
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(3) Leli Zeng1,?B. H. Jaswanth Gowda1,?Mohammed Gulzar Ahmed,?Mohammed A. S. Abourehab,?Zhe-Sheng Chen,?Changhua Zhang*,?Jia Li*,?Prashant Kesharwani*, Advancements in nanoparticle-based treatment approaches for skin cancer therapy, Molecular Cancer, 2023, 22(1):0-10. 中科院一區(qū) (IF=37.3)
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(4) Jia Li1, Leli Zeng1*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*, Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers, Advanced Materials, 2022, 34(1): 0-2100245. 中科院一區(qū) (IF=29.4)
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(5) Johannes Karges1, Jia Li1, Leli Zeng, Hui Chao*, Gilles Gasser*, Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy, ACS Applied Materials & Interfaces, 2020, 12(49): 54433-54444. 中科院一區(qū) (IF=9.5)
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(6) Jia Li, Hongmin Chen, Leli Zeng, Thomas W. Rees, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, Mitochondria- targeting cyclometalated iridium(III) complexes for tumor hypoxic imaging and therapy, Inorganic Chemistry Frontiers, 2019, 6(4): 1003-1010. 中科院一區(qū) (IF=7.0)
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(7) Jia Li, Leli Zeng, Kai Xiong, Thomas W. Rees, Chengzhi Jin, Weijun Wu, Yu Chen*, Liangnian Ji, Hui Chao*, A biotinylated ruthenium(ii) photosensitizer for tumor-targeted twophoton photodynamic therapy, Chemical Communications, 2019, 55(73): 10972-10975. 中科院二區(qū) (IF=4.9)
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(8) Leli Zeng 1, Jia Li 1, Chen Zhang, Yun-Kai Zhang, Wei Zhang, Juanjuan Huang, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, An organoruthenium complex overcomes ABCG2- mediated multidrug resistance via multiple mechanisms, Chemical Communications, 2019, 55(26): 3833-3836. 中科院二區(qū)(IF=4.9)
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