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個人簡介：
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博士生導(dǎo)師
廣東省骨科學(xué)重點(diǎn)實(shí)驗(yàn)室副主任
廣東省醫(yī)學(xué)杰出青年人才
中國老年學(xué)和老年醫(yī)學(xué)學(xué)會骨質(zhì)疏松分會創(chuàng)新與轉(zhuǎn)化專委會 常務(wù)委員/秘書
國際華人骨研協(xié)會（ICMRS）終身會員
中國醫(yī)師協(xié)會骨科醫(yī)師分會骨科基礎(chǔ)工作委員會委員
SICOT中國部骨科基礎(chǔ)學(xué)會第一屆委員會委員
中國生理學(xué)會基質(zhì)生物學(xué)分會青年學(xué)組委員
中國生物材料學(xué)會醫(yī)用金屬材料分會青年工作委員會委員
長期從事骨科基礎(chǔ)與臨床,、骨科生物材料的相關(guān)研究工作,。2016-2018年在瑞士AO國際骨科內(nèi)固定研究院從事骨科基礎(chǔ)研究2年。作為課題負(fù)責(zé)人主持包括國家自然科學(xué)基金區(qū)域聯(lián)合重點(diǎn)項(xiàng)目等骨科退變性疾病,、骨修復(fù)材料相關(guān)課題17項(xiàng),，作為子課題負(fù)責(zé)人參與國家重點(diǎn)研發(fā)計劃1項(xiàng)，作為主要研究人員參與了973課題,、國家自然科學(xué)基金重點(diǎn)項(xiàng)目等骨科基礎(chǔ)研究相關(guān)課題5項(xiàng),。尤其是作為課題負(fù)責(zé)人的骨科修復(fù)材料動態(tài)力學(xué)培養(yǎng)方向于 2023年獲得瑞士A0 foundation約380萬人民幣的科研資助。
在上述研究工作積累下,，在中山大學(xué)附屬第七醫(yī)院,、廣東省骨科學(xué)重點(diǎn)實(shí)驗(yàn)室建立了完善的動態(tài)力學(xué)培養(yǎng)系統(tǒng)、類器官制備平臺,、單細(xì)胞測序與分析平臺,；探索了應(yīng)激與穩(wěn)態(tài)維持相關(guān)基因調(diào)控骨形成的基因表達(dá)及其表觀遺傳學(xué)變化規(guī)律,；提出以功能為導(dǎo)向的類器官的構(gòu)建，并在此過程中發(fā)現(xiàn)動態(tài)力學(xué)能調(diào)節(jié)其免疫微環(huán)境,。發(fā)表SCI論文70余篇,，第一作者或通訊作者51篇。申請國家發(fā)明專利6項(xiàng),，公開5項(xiàng),，授權(quán)2項(xiàng)。主導(dǎo)完成Ⅱ類醫(yī)療器械注冊成功4項(xiàng),。擔(dān)任國際華人骨研協(xié)會(ICMRS)終身會員,，中國醫(yī)師協(xié)會骨科醫(yī)師分會骨科基礎(chǔ)工作委員會委員，SICOT中國部骨科基礎(chǔ)學(xué)會第一屆委員會委員,，中國生理學(xué)會基質(zhì)生物學(xué)分會青年學(xué)組委員,，中國生物材料學(xué)會醫(yī)用金屬材料分會青年工作委員會委員
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教育背景：
2009.09-2012.06 中山大學(xué)附屬第一醫(yī)院 博士學(xué)位
2005.09-2008.06 南通大學(xué)醫(yī)學(xué)院 碩士學(xué)位
1991.09-1995.06 萊陽衛(wèi)生學(xué)校 醫(yī)士
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教學(xué)情況：
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博士研究生：王建民 李俊宏 汪文濤 李海珍 陳泓坤 周家祥 李健
碩士研究生：王志凱
合作博士后：李先龍 李建峰
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科研工作：
1）研究方向：
1．動態(tài)力學(xué)下類器官構(gòu)建及應(yīng)用研究
2．干細(xì)胞及再生醫(yī)學(xué)，生物材料
3．骨科相關(guān)組織器官發(fā)育及退變研究（骨,、軟骨,、椎間盤等）
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本研究團(tuán)隊(duì)還將與國內(nèi)外多所知名院校和科研機(jī)構(gòu)如北京積水潭醫(yī)院、瑞士AO國際骨科內(nèi)固定研究院,、瑞士蘇黎世大學(xué)過敏與哮喘研究院,、英國諾丁漢大學(xué)、深圳大學(xué),、中國科學(xué)院深圳先進(jìn)技術(shù)研究院,、河北工業(yè)大學(xué)等開展廣泛和深入的合作，共同推進(jìn)課題進(jìn)展,。
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2）科研立項(xiàng)：
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1. 2024 廣東省科技廳 海外名師-團(tuán)隊(duì)類 AO國際骨科研究院轉(zhuǎn)化醫(yī)學(xué)名師團(tuán)隊(duì) 2024.09-2024.11 20萬元 主持
2. 2023年瑞士AOCMF國際合作項(xiàng)目 The application research of the instructive bone regenerating hydrogel under the dynamic mechanical microenvironment 380萬人民幣 主持
3. 2023 福建省衛(wèi)生健康委員會高層次人才團(tuán)隊(duì) 中山大學(xué)骨科基礎(chǔ)與轉(zhuǎn)化研究團(tuán)隊(duì) 2024.01-2028.12 ?63萬元/年×5=315萬元 ?帶頭人
4. 2022國家自然科學(xué)基金區(qū)域聯(lián)合重點(diǎn)項(xiàng)目U22A20162 基于梯度結(jié)構(gòu)和力學(xué)功能導(dǎo)向制備椎間盤類器官修復(fù)材料及再生機(jī)制研究（E0308）2023-01/2026-12 255萬元 ?主持
5. 2021國家自然科學(xué)基金面上項(xiàng)目 動態(tài)力學(xué)條件下PIEZO1/2介導(dǎo)調(diào)節(jié)類器官骨修復(fù)材料炎性微環(huán)境的作用及機(jī)制研究 32071351 ?2021/01-2024/12 ?61萬 ?主持
6. 深圳市科創(chuàng)委,，基礎(chǔ)研究,，JCYJ20190809142211354,，精準(zhǔn)仿生類器官骨修復(fù)材料的構(gòu)建及應(yīng)用基礎(chǔ)研究 2020/05-2023/01,， 20萬元 主持
7. 深圳市科創(chuàng)委國際合作項(xiàng)目 類器官骨修復(fù)材料的構(gòu)建和應(yīng)用基礎(chǔ)研究 GJHZ20180929160004704 2019 2019/09-2021/09 50萬 主持
8. 中山大學(xué)青年教師重點(diǎn)培育項(xiàng)目 間充質(zhì)干細(xì)胞亞群生物微加工構(gòu)建類器官骨修復(fù)材料 19ykzd05 ? 2019/01-2020/12 30萬 主持
9. 國家自然科學(xué)基金面上項(xiàng)目 透明質(zhì)酸活化CD44與HIF-1α信號通路協(xié)同促進(jìn)髓核組織再生的機(jī)理 81772400 ?2018/01-2021/12 55萬 主持
10. 國家重點(diǎn)研發(fā)計劃 華南生物醫(yī)用材料與植入器械創(chuàng)新示范基地子課題2017YFC1105000 ?2017/07-2020/12 ?86.88萬 骨干研究人員 主持
11. 廣州市產(chǎn)學(xué)研協(xié)同創(chuàng)新重大專項(xiàng) 基于三維培養(yǎng)的多種間充質(zhì)干細(xì)胞大規(guī)模擴(kuò)增體系建設(shè)及應(yīng)用研究 201604046028 2016/05-2019/04 ?50萬 ?分題負(fù)責(zé)人
12. Sino Swiss Science and Technology Cooperation Programme(SSSTC) EG-04-032015 Beta-catenin signaling in intervertebral degeneration disease 2016/01-2018/01 36 萬元 ?主持
13. ARI Project of feasibility the role of LncRNAs in degenerative disc disease and translational research PG108/5 2017/03-2018/02 14萬 ?主持
14. 中山大學(xué)附屬第七醫(yī)院啟動 關(guān)節(jié)軟骨衰老與退變單細(xì)胞圖譜演變及機(jī)制研究 20萬元
15. 廣東省自然科學(xué)基金 2014A030310466 腰椎間盤退變性疾病生物再生治療時間窗的研究 2015/01-2018/01 10萬元 主持
16. 中國博士后基金特別資助 2014T70826 恒河猴腰椎間盤退變再生治療時間窗的分子成像量化研究 2014/04-2016/04 15萬元 ?主持
17. 中國博士后基金 2013M531876 終板下骨注射平陽霉素建立恒河猴缺血性椎間盤退變模型 2013/04-2015/11 5萬元 ?主持
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3）科研論文（僅第一/通訊）：
1.? Zhou, Zhiyu#,，Jiang, Bo，Zhou, Zhiyang,，Pan, Ximin,，Sun, Haixing,，Huang, Baoding,，Liang, Tangzhao,，Ringgaard, Steffen，Zou, Xuenong*,，Intervertebral Disk Degeneration: T1 rho MR Imaging of Human and Animal Models,，Radiology，2013.8.01，268（2）：492~500
2.? Zhang, P.#, X. Liu#, P. Guo#, X. Li, Z. He, Z. Li, M. J. Stoddart, S. Grad, W. Tian, D. Chen*, X. Zou*, Z. Zhou* and S. Liu (2021). "Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration." Bioactive Materials 6(10): 3097-3108. DOI:10.1016/j.bioactmat.2021.02.024.?
3.? Peng Guo#, Xizhe Liux#, Penghui Zhang#, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqiang Zhou, Xuenong Zou, Danny Channy, Wei Tian, Dafu Chen*, Manman Gao*, Zhiyu Zhou*, Shaoyu Liu A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration. Bioact Mater. 2022 11;9:281-298.?
4.? Ma J, Guo W, Gao M, Huang B, Qi Q, Ling Z, Chen Y, Hu H, Zhou H, Yu F, Chen K, Richards G, Lin J, Zhou Z*, Xiao D*, Zou X*. Biomimetic matrix fabricated by LMP-1 gene-transduced MC3T3-E1 cells for bone regeneration. Biofabrication. 2017 Nov 14;9(4):045010. doi: 10.1088/1758-5090/aa8dd1
5.? Zhou, Zhiyu, Wentao Wang, Jianmin Wang, Hongshui Wang, Yi Xia, Wei Zhang, Yuxiao Lai et al. "Function-oriented design: A novel strategy for advanced biomedical materials." Journal of Materials Science & Technology 145 (2023): 197-209.?
6.? Ma, Junxuan#,，Zhou, Zhiyu#，Gao, Manman,，Yu, Binsheng,，Xiao, Deming*，Zou, Xuenong*,，B¨1nger, Cody*,，Biosynthesis of Bioadaptive Materials: A Review on Developing Materials Available for Tissue Adaptation，Journal of Materials Science & Technology,，Volume 32, Issue 9, September 2016, Pages 810-814?
7.? Chen, Shaoming#,，Gao, Manman#，Zhou, Zhiyu#,，Liang, Jiabi,，Gong, Ming，Dai, Xuejun,，Liang, Tangzhao,，Ye, Jiacheng，Wu, Gang,，Zou, Lijin,，wang yingjun，Zou Xuenong*,，Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia,，Journal of Materials Science & Technology(1005-0302)，2016.08.03,，32（9）：978~985?
8.? Zhou ZhiYu,，Zou LiJin，Li HaiSheng,，Bunger Cody,，Zou XueNong(*)，An overview on bone protein extract as the new generation of demineralized bone matrix,，Science China Life Sciences,，2012.12.01，55（12）：1045~1056?
9.? Li, Baoliang, Xu Chen, Hongkun Chen, Fu Zhang, Jianfeng Li, Zhengya Zhu, Tao Tang et al. "A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration." Biomolecules and Biomedicine 25, no. 3 (2025): 708-719.
10.? Wang, Fuan, Hongkun Chen, Zhongyuan He, Jianfeng Li, Zhengya Zhu, Tao Tang, Junhong Li et al. "Cellular response to short-time mechanical stimuli: mediating Ca 2+ influx via PIEZO1." European Cells and Materials 48 (2024): 1-16.
11.? Zhou, Jiaxiang, Jianmin Wang, Jianfeng Li, Zhengya Zhu, Zhongyuan He, Junhong Li, Tao Tang et al. "Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc." JOR spine 7, no. 1 (2024): e1314.
12.? Li, Junhong, Jianfeng Li, Chengkai Lin, Jiaxiang Zhou, Jianmin Wang, Fuan Wang, Haizhen Li, and Zhiyu Zhou. "Genetically proxied PCSK9 inhibition is associated with reduced psoriatic arthritis risk." Inflammation Research 73, no. 3 (2024): 475-484.
13.? Chen, Dafu, Jiaxiang Zhou, Chengkai Lin, Junhong Li, Zhengya Zhu, Xuezhi Rao, Jianmin Wang et al. "A causal examination of the correlation between hormonal and reproductive factors and low back pain." Frontiers in Endocrinology 15 (2024): 1326761.
14.? He, Zhongyuan, Tao Tang, Zhengya Zhu, Fuan Wang, Jianfeng Li, Fu Zhang, Nguyen Tran Canh Tung, Shaoyu Liu, Xizhe Liu, and Zhiyu Zhou. "Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes." JOR spine 7, no. 3 (2024): e1350.
15.? Li, Jianfeng, Junhong Li, Xianlong Li, Wei Wang, Yi Ding, Jiaxiang Zhou, Wentao Wang et al. "Identification of coagulation diagnostic biomarkers related to the severity of spinal cord injury." International Immunopharmacology 137 (2024): 112505.
16.? He, Zhongyuan, Zhengya Zhu, Tao Tang, Fuan Wang, Peng Guo, Jianfeng Li, Nguyen Tran Canh Tung et al. "Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging." Journal of Bone and Mineral Metabolism (2024): 1-18.
17.? Zhu, Z., T. Tang, Z. He, F. Wang, H. Chen, G. Chen, J. Zhou et al. "Uniaxial cyclic stretch enhances osteogenic differentiation of OPLL-derived primary cells via YAP-Wnt/β-catenin axis." Eur. Cell Mater 45 (2023): 31-45.
18.? Zhu Y, Lu Y, Zhou C, Tong G, Gao M, Zhan Y, Wang Y, Liang R, Li Y, Gao T, Wang L, Zhang M, Cheng J, Gong J, Wang J, Zhang W, Qi J, Cui M, Zhu L, Xiao F, Zhu L, Xu Y, Zheng Z, Zhou Z, Cheng Z, Hong P. Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines. Med (N Y). 2022 Jun 8:S2666-6340(22)00219-7. doi: 10.1016/j.medj.2022.05.003. Epub ahead of print. PMID: 35679856; PMCID: PMC9181311.
19.? Bao-Liang Li, Xizhe Liu, Manman Gao, Fu Zhang, Xu Chen, Zhongyuan He, Jianmin Wang, Wei Tian, Dafu Chen*, Zhiyu Zhou*, Shaoyu Liu Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Oxid Med Cell Longev . 2021 Aug 31;2021:5608133. doi: 10.1155/2021/5608133. eCollection
20.? Zhu Z, He Z, Tang T, Wang F, Chen H, Li B, Chen G, Wang J, Tian W, Chen D, Wu X, Liu X, Zhou Z, Liu S. Integrative Bioinformatics Analysis Revealed Mitochondrial Dysfunction-Related Genes Underlying Intervertebral Disc Degeneration. Oxid Med Cell Longev. 2022 Oct 11;2022:1372483. doi: 10.1155/2022/1372483. PMID: 36267810; PMCID: PMC9578809.?
21.? Chen X#, Chen H#, Li BL, Xiao Z, Zhou Y, Tian W, Chen D, Liu X*, Zhou Z*, Liu S. Dynamic elastic modulus assessment of the early degeneration model of an intervertebral disc in cynomolgus monkeys with one strike loading. Comput Methods Programs Biomed. 2022 Jun 30;224:106982. doi: 10.1016/j.cmpb.2022.106982. Epub ahead of print. PMID: 35797747.?
22.? Gao M, Liu X, Guo P, Wang J, Li J, Wang W, Stoddart MJ, Grad S, Li Z, Wu H, Li B, He Z, Zhou G, Liu S, Zhu W*, Chen D*, Zou X*, Zhou Z*. Deciphering postnatal limb development at single-cell resolution. iScience. 2022 Dec 13;26(1):105808. doi: 10.1016/j.isci.2022.105808. PMID: 36619982; PMCID: PMC9813795.?
23.? Zhang F*, Wang S*, Gao M, Li B, He Z, Tang T, Zhu Z, Liu S#, Zhou Z#. Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation. Front Bioeng Biotechnol. 2022 Dec 16;10:1057429. doi: 10.3389/fbioe.2022.1057429. PMID: 36588938; PMCID: PMC9800418.?
24.? Zhang F, Wang S, Gao M, Li B, He Z, Tang T, Zhu Z, Liu S, Zhou Z. Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation. Front Bioeng Biotechnol. 2022 Dec 16;10:1057429. doi: 10.3389/fbioe.2022.1057429. PMID: 36588938; PMCID: PMC9800418.
25.? He Z, Zhu Z, Tang T, Guo P, Gao M, Li B, Nguyen TCT, Chen H, Liu X, Zhou Z, Liu S. Characterization of ligamentum flavum hypertrophy based on m6A RNA methylation modification and the immune microenvironment. Am J Transl Res. 2022 Dec 15;14(12):8800-8827. PMID: 36628248; PMCID: PMC9827295.
26.? Zhiyu Zhou, Shangbin Cui, Jie Du, R. Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li. One Strike Loading Organ Culture Model to Investigate the Post-traumatic Disc Degenerative Condition. J Orthop Translat. 2020 Oct 20;26:141-150. doi: 10.1016/j.jot.2020.08.003. eCollection 2021 Jan.?
27.? Zhiyu Zhou , Stephan Zeiter , Tanja Schmid , Daisuke Sakai , James C. Iatridis , Guangqian Zhou , R. Geoff Richards, Mauro Alini , Sibylle Grad , and Zhen Li Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration ?Cartilage 2020 https://doi.org/10.1177/1947603518764263
28.? Wen L, Gao M, He Z, Guo P, Liu Z, Zhang P, Zhang F, Chen D, Zhou G, Zhou Z. Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis. Biochem Biophys Res Commun. 2021 Sep 17;570:199-205. doi: 10.1016/j.bbrc.2021.07.044. Epub 2021 Jul 20. PMID: 34298323..?
29.? Tang, Tao, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu#, Zhiyu Zhou#, Shaoyu Liu. "DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling." JOR Spine (2023): e1247.?
30.? Wang J, Zhu P, Pan X, Yang J, Wang S, Wang W, Li B, Zhu Z, Tang T, Chen D, Gao M, Zhou Z. Correlation between motor behavior and age-related intervertebral disc degeneration in cynomolgus monkeys. JOR Spine. 2022 Jan 1;5(1):e1183. doi: 10.1002/jsp2.1183. PMID: 35386757; PMCID: PMC8966873.?
31.? F. Zhang#, S. Wang#, B. Li, W. Tian, Z. Zhou*, S. Liu*, Intradiscal injection for the management of low back pain, JOR SPINE 2021 n/a(n/a) e1186.?
32.? S. Cui, Z. Zhou#, X. Chen, F. Wei, R.G. Richards, M. Alini, S. Grad, Z. Li, Transcriptional profiling of intervertebral disc in a post-traumatic early degeneration organ culture model, JOR SPINE 2021 Apr 8;4(3):e1146. doi: 10.1002/jsp2.1146. eCollection 2021 Sep.?
33.? Zhengya Zhu, Tao Tang, Zhongyuan He, Fuan Wang, Hongkun Chen,，Guoliang Chen , Jiaxiang Zhou, Shengkai Liu, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu#, Zhiyu Zhou#, Shaoyu Liu ?Uniaxial Cyclic Stretch Enhances Osteogenic Differentiation of OPLL Derived Primary Cells via YAP-Wnt/β-catenin Axis eCM 2023 2023 Feb 7;45:31-45. doi: 10.22203/eCM.v045a03.
34.? He Z, Zhu Z, Tang T, Guo P, Gao M, Li B, Nguyen TCT, Chen H, Liu X#, Zhou Z#, Liu S. Characterization of ligamentum flavum hypertrophy based on m6A RNA methylation modification and the immune microenvironment. Am J Transl Res. 2022 Dec 15;14(12):8800-8827. PMID: 36628248; PMCID: PMC9827295.
35.? Li J, Wu H, Liu X, Guo P, He Z, Wen L, Tian W, Chen D, Gao M, Zhou Z, Liu S. A new method for preparing single-cell nuclear suspension of frozen spinal cord tissue. J Neurosci Methods. 2022 Mar 15;370:109490. doi: 10.1016/j.jneumeth.2022.109490. Epub 2022 Jan 25. PMID: 35090902.?
36.? Li J, Liu X, Wu H, Guo P, Li B, Wang J, Tian W, Chen D, Gao M, Zhou Z, Liu S. Identification of hub genes related to the innate immune response activated during spinal cord injury. FEBS Open Bio. 2022 Oct;12(10):1839-1856. doi: 10.1002/2211-5463.13472. Epub 2022 Sep 1. PMID: 36047918; PMCID: PMC9527585
37.? Wu H, Tong K, Liu X, Li J, Li X, Gao M, Tian W, Chen D, Zhou Z, Liu S. A comparison between two laminectomy procedures in mouse spinal cord injury on Allen's animal model. J Neurosci Methods. 2022 Feb 15;368:109461. doi: 10.1016/j.jneumeth.2021.109461. Epub 2021 Dec 24. PMID: 34958819.?
38.? Shangbin Cui#, Zhiyu Zhou#, Xizhe Liu, R. Geoff Richards, Mauro Alini,Songlin Peng, Shaoyu Liu, Xuenong Zou, Zhen Li, Sibylle Grad* Identification and Characterization of Serum microRNAs as Biomarkers for Human Disc Degeneration: An RNA Sequencing Analysis. diagnostics 2020, 10(12) , 1063
39.? Gao MM#, Su QN#, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY#, Zou NX#1. Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes. Eur Cell Mater. 2018 Jul 25;36:1-14. doi: 10.22203/eCM.v036a01.?
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